Magnetic resonance imaging combined with serum endolipin and galactagoglobin-3 to diagnose cerebral infarction in the elderly with diabetes mellitus

Table 1 Comparison of clinical data between the two patient groups

Indicators	Diabetic cerebral infarction group (n = 62)	Non-diabetic cerebral infarction group (n = 88)	t/χ2	P value
Gender (cases)
Male	36	50	0.023	0.879
Female	26	38
Smoking history (cases)
Yes	21	30	0.001	0.978
No	41	58
Drinking history (cases)
Yes	15	21	0.002	0.963
No	47	67
Infarction location (cases)
Left side	32	45	0.003	0.954
Right side	30	43
Age (yr)	68.85 ± 4.18	69.10 ± 4.24	0.128	0.721
Diastolic blood pressure (mmHg)	76.53 ± 3.34	76.10 ± 3.40	0.59	0.444
Systolic blood pressure (mmHg)	121.23 ± 8.53	120.76 ± 8.64	0.109	0.742
BMI index (kg/m2)	22.04 ± 4.16	21.89 ± 4.20	0.047	0.829
Lesion volume (cm3)	8.80 ± 1.16	8.74 ± 1.21	0.093	0.761
Time from onset to admission (h)	2.50 ± 1.03	2.53 ± 1.05	0.03	0.862
Waist circumference (cm)	82.05 ± 8.56	81.78 ± 8.62	0.036	0.85

BMI: Body mass index.

Table 2 Comparison of serum endolipin and galactagoglobin-3 expression in the two groups

Group	Visfatin (µg/L)	Gal-3 (ng/mL)
Diabetic cerebral infarction group (n = 62)	36.58 ± 8.12	10.58 ± 3.48
Non-diabetic cerebral infarction group (n = 88)	26.13 ± 6.82	6.28 ± 2.39
t	8.536	8.975
P value	< 0.001	< 0.001

Gal-3: Galactagoglobin-3.

Table 3 Comparison of arterial lumen examination parameters between the two groups

Group	VA (mm2)	LA (mm2)	WA (mm2)	NWI	Stenosis rate (%)
Diabetic cerebral infarction group (n = 62)	131.28 ± 24.23	67.14 ± 18.53	58.15 ± 6.64	0.48 ± 0.10	48.52 ± 12.08
Non-diabetic cerebral infarction group (n = 88)	118.82 ± 21.02	65.82 ± 16.20	48.28 ± 6.35	0.42 ± 0.08	36.12 ± 8.83
t	3.555	0.463	9.199	4.075	7.264
P value	0.001	0.644	< 0.001	< 0.001	< 0.001

VA: Vessel area; LA: Lumen area; WA: Wall area; NWI: Normalized wall index.

Table 4 Comparison of plaque nature detection in the two groups, n (%)

Group	Necrotic lipid nuclear plaque	Plaque intraplaque hemorrhage	Plaque ulceration	Plaque calcification	Total
Diabetic cerebral infarction group (n = 62)	36 (58.06)	8 (12.90)	3 (4.84)	13 (20.97)	60 (96.77)
Non-diabetic cerebral infarction group (n = 88)	23 (26.14)	15 (17.05)	10 (11.36)	13 (14.77)	61 (69.32)
Z	15.539	0.481	1.956	0.974	17.582
P value	< 0.001	0.488	0.162	0.324	< 0.001

In the above tables, values followed by parentheses indicate the share of the indicator in the corresponding group.

Table 5 Clinical value of MRI combined with serum endostatin and galactagoglobin-3 in the diagnosis of diabetic cerebral infarction

Indicators	AUC	Youden index	Sensitivity (%)	Specificity (%)	SE	95%CI
MRI	0.858	0.605	94.30	66.10	0.0317	0.792-0.910
Visfatin	0.784	0.481	85.20	62.90	0.0383	0.710-0.847
Gal-3	0.807	0.521	79.50	72.60	0.0378	0.735-0.867
MRI combined with serum Visfatin and Gal-3	0.981	0.846	94.30	90.30	0.00865	0.944-0.996

MRI: Magnetic resonance imaging; Gal-3: Galactagoglobin-3; AUC: Area under the curve.