Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2024; 15(7): 1509-1517
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1509
Magnetic resonance imaging combined with serum endolipin and galactagoglobin-3 to diagnose cerebral infarction in the elderly with diabetes mellitus
Yan-Hui Zhang, Dong Liang
Yan-Hui Zhang, Magnetic Resonance Imaging Room, Tianjin Huanhu Hospital, Tianjin 300350, China
Dong Liang, Department of Endocrinology, Tianjin First Central Hospital, Tianjin 300190, China
Author contributions: Zhang YH designed the study; Liang D contributed to the analysis of the manuscript; Zhang YH and Liang D involved in the data and writing of this article; and all authors have read and approved the final manuscript. Zhang YH and Liang D contributed equally to this work.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Tianjin Huanhu Hospital.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: No other data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Hui Zhang, MMed, Attending Doctor, Magnetic Resonance Imaging Room, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin 300350, China. yuanhetan576183@163.com
Received: February 26, 2024
Revised: April 7, 2024
Accepted: April 26, 2024
Published online: July 15, 2024
Processing time: 133 Days and 6.8 Hours
Abstract
BACKGROUND

Magnetic resonance imaging (MRI) combined with serum endothelin and galactagoglobin-3 (Gal-3) can improve the clinical diagnosis of diabetes mellitus complicated with cerebral infarction.

AIM

To analyze the clinical value of MRI combined with serum endolipin and Gal-3 for the diagnosis of cerebral infarction in the elderly with diabetes mellitus.

METHODS

One hundred and fifty patients with acute cerebral infarction hospitalized between January 2021 and December 2023 were divided into two groups according to comorbid diabetes mellitus, including 62 and 88 cases in the diabetic and nondiabetic cerebral infarction groups. Serum samples were collected to detect the expression of serum endolipoxins, and Gal-3, and cranial MRI was performed at admission. Differences between the two groups were compared to analyze the diagnostic value of these parameters.

RESULTS

Serum endolipin and Gal-3 expression were higher in the diabetic cerebral infarction group (P < 0.05). The arterial wall area, vessel area, normalized wall index, and lumen stenosis rate were higher in the diabetic cerebral infarction group, while the rate of arterial lumen moderate and severe stenosis was 48.39% higher (36.36%, P < 0.05). The percentage of large (29.03%) and multiple infarcts (33.87%) in the diabetic cerebral infarction group was higher (13.64% and 20.45%), and the incidence rate of lacunar infarcts was lower (37.10% vs 65.91%) (P < 0.05). The total incidence of arterial plaque in patients in the diabetic cerebral infarction group was 96.77% higher (69.32%), while the incidence of necrotic lipid core plaque was 58.06% higher (26.14%) (P < 0.05). Receiver operating characteristic curve analysis was performed to assess the diagnosis utility of these techniques. MRI in combination with serum endoglin and Gal-3 had the highest area under the curve, the Yoden index, sensitivity and specificity (P < 0.05).

CONCLUSION

The expression of serum endolipin and Gal-3 in elderly patients with diabetes mellitus with cerebral infarction showed an elevated trend, and the degree of luminal stenosis was severe. MRI predominantly revealed large and multiple infarct foci. This combined index examination can improve the clinical diagnosis of diabetes mellitus combined with cerebral infarction.

Keywords: Endolipin; Galectin-3; Magnetic resonance imaging; Elderly; Diabetes mellitus; Cerebral infarction

Core Tip: Magnetic resonance imaging (MRI) and serum markers aid diagnosis of cerebral infarction in elderly diabetics. Elevated serum endolipin and galactagoglobin-3 levels were observed in diabetic patients. MRI revealed severe luminal stenosis and multiple infarct foci. Combined with serum markers, MRI showed the highest diagnostic utility. This study highlights the clinical value of these techniques for diagnosing cerebral infarction in elderly diabetics.