Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment

doi:10.4239/wjd.v15.i4.735

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Apr 15, 2024 (publication date) through May 4, 2024

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World Journal of Diabetes

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Apr 15, 2024; 15(4): 735-757
Published online Apr 15, 2024. doi: 10.4239/wjd.v15.i4.735

Table 1 Eleven potential compounds were selected by Comparative Toxicogenomics Database

Target gene	Chemical name	Chemical formula	Interaction
RAC3	11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	C₂₁H₂₈O₄	Affects methylation[84]/increases abundance
RAC3	Benzo(a)pyrene	C₂₀H₁₂	Increases methylation[85]
RAC3	Bis(4-hydroxyphenyl)sulfone	C₁₂H₁₀O₄S	Increases methylation[86]
RAC3	Bisphenol A	C₁₅H₁₆O₂	Decreases methylation[87]
RAC3	Cannabinoids	C₂₁H₃₀O₂	Affects methylation[84]/increases abundance
RAC3	Cyclosporine	C₆₂H₁₁₁N₁₁O₁₂	Decreases methylation[88]
RAC3	Valproic Acid	C₈H₁₆O₂	Increases methylation[89]
TFRC	Choline	C₅H₁₄NO₊	Affects cotreatment[90]/decreases methylation
TFRC	Folic Acid	C₁₉H₁₉N₇O₆	Affects cotreatment[90]/decreases methylation
TFRC	Methionine	C₅H₁₁NO₂S	Affects cotreatment[90]/decreases methylation
TFRC	Vinclozolin	C₁₂H₉C_l2NO₃	Increases methylation[91]

Names, molecular formulas and interaction with target genes are shown.

Citation: Gao J, Zou Y, Lv XY, Chen L, Hou XG. Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment. World J Diabetes 2024; 15(4): 735-757
URL: https://www.wjgnet.com/1948-9358/full/v15/i4/735.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i4.735