Comprehensive analysis of endoplasmic reticulum stress-related mechanisms in type 2 diabetes mellitus

doi:10.4239/wjd.v14.i6.820

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2023; 14(6): 820-845
Published online Jun 15, 2023. doi: 10.4239/wjd.v14.i6.820

Table 1 20 key genes

Gene	Description	MCC-score	Degree	Closeness	Betweenness
COL3A1	Collagen Type III Alpha 1 Chain	11179	16	64.5	1189.37723
COL6A3	Collagen Type VI Alpha 3 Chain	11168	12	62.03333	567.89507
COL4A1	Collagen Type IV Alpha 1 Chain	11167	12	59.91667	480.86034
COL4A2	Collagen Type IV Alpha 2 Chain	10806	10	56.23333	84.68666
COL11A1	Collagen Type XI Alpha 1 Chain	10800	9	54.5	18.34225
PLOD2	Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2	10326	10	56.88333	112.4573
COL22A1	Collagen Type XXII Alpha 1 Chain	10080	8	51.80952	4.88333
SERPINH1	Serpin Family H Member 1	6001	10	60.3	1308.02191
P4HA1	Prolyl 4-Hydroxylase Subunit Alpha 1	5166	9	55.07857	68.74063
MCM7	Minichromosome Maintenance Complex Component 7	1804	14	68.24286	1418.45764
MCM2	Minichromosome Maintenance Complex Component 2	1801	13	63.94524	784.74991
MSH2	MutS Homolog 2	1645	12	62.22619	646.66407
TIPIN	TIMELESS Interacting Protein	1596	10	54.1631	37.22401
SMC2	Structural Maintenance of Chromosomes 2	1567	10	53.77976	230.10198
POLA2	DNA Polymerase Alpha 2, Accessory Subunit	1560	8	52.6131	4.22778
ESPL1	Extra Spindle Pole Bodies Like 1, Separase	962	10	56.52976	455.86734
POSTN	Periostin	860	15	66.51667	1995.77049
SKP2	S-Phase Kinase Associated Protein 2	771	13	64.5619	1861.813
TRIM32	Tripartite Motif Containing 32	722	8	54.52976	282.93712
SIAH2	Siah E3 Ubiquitin Protein Ligase 2	722	8	57.06905	982.96735

MCC: McCormick.

Citation: Liang B, Chen SW, Li YY, Zhang SX, Zhang Y. Comprehensive analysis of endoplasmic reticulum stress-related mechanisms in type 2 diabetes mellitus. World J Diabetes 2023; 14(6): 820-845
URL: https://www.wjgnet.com/1948-9358/full/v14/i6/820.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i6.820