Changes and significance of retinal blood oxygen saturation and oxidative stress indexes in patients with diabetic retinopathy

Table 1 The baseline data of the study subjects, n (%)

Group	DR group (n = 94)	Control group (n = 100)	t/χ2 value	P value
Age (yr)	65.8 ± 7.0	64.4 ± 8.1	1.284	0.201
BMI (kg/m2)	24.6 ± 1.9	24.4 ± 2.0	0.713	0.477
Sex			1.195	0.274
Male	51 (54.26)	62 (62.00)
Female	43 (45.74)	38 (38.00)
Affected side distribution			1.959	0.162
Left side	47 (50.00)	60 (60.00)
Right	47 (50.00)	40 (40.00)
Hypertension			2.561	0.110
Yes	18 (19.15)	29 (29.00)
No	76 (80.85)	71 (71.00)
Dyslipidemia			1.909	0.176
Yes	32 (34.04)	25 (25.00)
No	62 (65.96)	75 (75.00)

DR: Diabetic retinopathy; BMI: Body mass index.

Table 2 Comparison of serum oxidative stress indicators between the two groups of subjects (mean ± SD)

Group	DR group (n = 94)	Control group (n = 100)	t value	P value
MDA (μmol/L)	7.50 ± 1.50	3.82 ± 0.84	21.246	< 0.05
8-HdG (ng/mL)	107.50 ± 22.51	49.63 ± 8.11	24.102	< 0.05
SOD (U/L)	71.33 ± 14.80	93.64 ± 17.26	-9.637	< 0.05
GSH (mg/L)	163.81 ± 38.51	211.07 ± 25.46	-10.14	< 0.05

MDA: Serum malondialdehyde; 8-HdG: 8-hydroxydehydroguanosine; SOD: superoxide dismutase; GSH: Reduced glutathione.

Table 3 Comparison of serum oxidative stress indexes in patients with different diabetic retinopathy stages (mean ± SD)

Disease classification	Simple (n = 56)	Proliferative (n = 38)	t value	P value
MDA (μmol/L)	6.11 ± 1.38	9.55 ± 1.43	-11.688	< 0.05
8-HdG (ng/mL)	90.53 ± 20.54	132.51 ± 19.82	-9.862	< 0.05
SOD (U/L)	83.02 ± 11.68	54.10 ± 13.01	11.249	< 0.05
GSH (mg/L)	187.46 ± 32.74	128.96 ± 26.74	9.135	< 0.05

MDA: Serum malondialdehyde; 8-HdG: 8-hydroxydehydroguanosine; SOD: superoxide dismutase; GSH: Reduced glutathione.