Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters

Table 1 Demographic, clinical and biochemical parameters of the study population vs controls

	Obese subjects	Controls	P value
Male/Female (n)	21/81	9/21	0.3234
Age (yr)	62.14 (10.19)	44.60 (18.76)	< 0.0001
BMI (kg/m2)	35.75 (3.75)	24.56 (1.78)	< 0.0001
WC (cm)	106.58 (13.27)	96.38 (3.76)	< 0.0001
FPG (mg/dL)	117.56 (42.13)	92.63 (7.60)	0.0016
TC (mg/dL)	228.66 (45.22)	137.70 (20.46)	< 0.0001
HDL-c (mg/dL)	47.72 (12.68)	66.23 (10.85)	< 0.0001
LDL-c (mg/dL)	141.78 (42.43)	106.93 (15.93)	< 0.0001
TG (mg/dL)	156.98 (92.25)	95.77 (20.22)	0.0005
UA (mg/dL)	4.44 (1.18)	3.80 (0.92)	0.0073
eGFR (mL/min/1.73 m2)	68.49 (18.84)	106.77 (17.75)	< 0.0001
FORT (mmol/L H2O2)	3.04 (0.36)	2.03(0.14)	< 0.0001
FORD (mmol/L Trolox)	1.27 (0.13)	1.87 (1.20)	0.0072

Data are presented as mean ± SD or as n. BMI: Body mass index; WC: Waist circumference; FGP: Fasting plasma glucose; TC: Total cholesterol; HDL-c: High-density lipoprotein cholesterol; LDL-c: Low-density lipoprotein cholesterol; TG: Triglycerides; UA: Uric acid; eGFR: Estimated glomerular filtration rate; FORT: Free oxygen radical test; FORD: Free oxygen radical defence.

Table 2 Demographic, clinical and biochemical parameters of obese type 2 diabetes mellitus subjects vs obese non-diabetic patients

	T2DM	Obese non-diabetic subjects	P value
Male/Female (n)	6/27	15/54	0.7965
Age (yr)	66.45 (9.78)	60.07 (9.79)	0.0027
BMI (kg/m2)	36.66 (4.01)	35.32 (3.57)	0.0920
WC (cm)	107.24 (13.91)	106.26 (13.04)	0.7286
FPG (mg/dL)	153.32 (56.94)	100.45 (13.91)	< 0.0001
TC (mg/dL)	231.92 (46.75)	227.11 (44.74)	0.6180
HDL-c (mg/dL)	43.98 (10.48)	49.51 (13.30)	0.0384
LDL-c (mg/dL)	137.54 (38.10)	143.80 (44.47)	0.4885
TG (mg/dL)	149.41 (111.44)	160.60 (82.18)	0.5690
UA (mg/dL)	4.70 (1.33)	4.32 (1.10)	0.1319
FORT (mmol/L H2O2)	3.16 (0.39)	2.99 (0.33)	0.0233
FORD (mmol/L Trolox)	0.67 (0.15)	0.72 (0.14)	0.0649

Data are presented as mean ± SD or as n. T2DM: Type 2 diabetes mellitus; BMI: Body mass index; WC: Waist circumference; FGP: Fasting plasma glucose; TC: Total cholesterol; HDL-c: High-density lipoprotein cholesterol; LDL-c: Low-density lipoprotein cholesterol; TG: Triglycerides; UA: Uric acid; eGFR: Estimated glomerular filtration rate; FORT: Free oxygen radical test; FORD: Free oxygen radical defence.