Diabetes-related impairment in bone strength is established early in the life course

Figure 1 Comparison of blood glucose (mg/dL) in non-obese diabetic (dark gray bars) and syngenic non-diabetic (light gray bars) mice at 11 and 15 wk demonstrates initiation of the type 1 diabetic phenotype. Error bars represent SEM. At five, eight (data not shown) and eleven there was no difference in blood glucose levels between strains of mice. ^aHowever at 15 wk, non-obese diabetic mice had significantly greater blood glucose than NOD.scid mice and concentration was indicative of diabetes (< 120 mg/dL).

Figure 2 Comparison of changes in body composition parameters as assessed by dual-energy X-ray absorptiometry at 5, 8, 11 and 15 wk. ^aNon-obese diabetic mice were significantly heavier.

Figure 3 Tibia strength by 3-point breakage analysis using the NTS 85MTS Minibionix8 with a 100 N load cell. The span was 9 mm and the bones were loaded with a rate of 0.1 mm/s to evaluate maximum load to failure in 5 and 8 wk in non-obese diabetic (dark gray bars) and syngenic non-diabetic (light gray bars). Error bars represent SEM. ^aNon-obese diabetic mice demonstrated less mechanical strength than syngenic non-diabetic mice at 5 wk.