Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy

doi:10.4239/wjd.v16.i1.100376

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Jan 15, 2025 (publication date) through Dec 2, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2025; 16(1): 100376
Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.100376

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Figure 1 Intestinal bacteria and type 2 diabetes mellitus. TM2D: Type 2 diabetes mellitus.

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Figure 2 Mechanisms of action of specific gut microbiota affecting various organs. The left side illustrates the mechanisms by which beneficial bacteria, such as Bifidobacterium, affect the skin, kidneys, and brain, while the right side shows the impact of harmful bacteria like Fusobacterium on these organs. CYSC: Cystatin; EGFR: Estimated glomerular filtration rate; GLP-1: Glucagon-like peptide-1; IL: Interleukin; LPS: Lipopolysaccharide; PRO: Protein; PCS: Phosphatidylcholines; SCr: Sex combs reduced; SCFAs: Short-chain fatty acids; TGF-β1: Transforming growth factor β1; TNFR1: Tumor necrosis factor receptor 1.

Citation: Wen X, Qi LM, Zhao K. Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy. World J Diabetes 2025; 16(1): 100376
URL: https://www.wjgnet.com/1948-9358/full/v16/i1/100376.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i1.100376