Wen X, Qi LM, Zhao K. Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy. World J Diabetes 2025; 16(1): 100376 [DOI: 10.4239/wjd.v16.i1.100376]
Corresponding Author of This Article
Kui Zhao, PhD, Associate Professor, Research Scientist, Senior Scientist, College of Materials and Chemical Engineering, Southwest Forestry University, No. 300 White Dragon Temple, Panlong District, Kunming 650224, Yunnan Province, China. zhao10028tcm@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jan 15, 2025; 16(1): 100376 Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.100376
Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy
Xue Wen, Lu-Ming Qi, Kui Zhao
Xue Wen, Lu-Ming Qi, College of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, Sichuan Province, China
Kui Zhao, College of Materials and Chemical Engineering, Southwest Forestry University, Kunming 650224, Yunnan Province, China
Co-corresponding authors: Lu-Ming Qi and Kui Zhao.
Author contributions: Wen X designed and wrote the manuscript; Qi LM supervised the guidance of the manuscript; Zhao K provided financial support for this work; all of the authors read and approved the final version of the manuscript to be published.
Supported by "Caiyun Postdoctoral Program" of Innovation Project, 2023.
Conflict-of-interest statement: All other authors declare no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kui Zhao, PhD, Associate Professor, Research Scientist, Senior Scientist, College of Materials and Chemical Engineering, Southwest Forestry University, No. 300 White Dragon Temple, Panlong District, Kunming 650224, Yunnan Province, China. zhao10028tcm@126.com
Received: August 14, 2024 Revised: October 20, 2024 Accepted: November 8, 2024 Published online: January 15, 2025 Processing time: 107 Days and 12.8 Hours
Abstract
The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the gut microbiome a new potential therapeutic focus. This commentary examines the recent publication in World Journal of Diabetes. The article explores the association between T2DM and gut microbiota, with a focus on the pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such approaches. This editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic axis. It provides new insights for future research on gut-microbiota-based interventions for T2DM.
Core Tip: Our editorial uncovers the pivotal role of the gut microbiome in type 2 diabetes mellitus (T2DM), pinpointing microbial imbalances as therapeutic targets. It explores the mechanisms behind the cross-tissue effects of gut bacteria on T2DM and its complications, suggesting that probiotics, prebiotics or fecal transplantation may offer a promising new path to combat this escalating global health issue.
