Molecular targets and mechanisms of Jiawei Jiaotai Pill on diabetic cardiomyopathy based on network pharmacology

Figure 1 Venn diagram of the common target of Jiawei Jiaotai pill and diabetic cardiomyopathy. Drug: Jiawei Jiaotai pill; Disease: Diabetic cardiomyopathy.

Figure 2 Protein-protein interaction network diagram of Jiawei Jiaotai pill in the treatment of diabetic cardiomyopathy.

Figure 3 Topology calculation process diagram of key targets. A: In the initial screening, 33 targets were found to exceed the average degree of freedom of all other targets; B: In the second screening, 30 targets were found that exceeded the average closeness of all targets; C: In the third screening, 18 targets were found that exceeded the average betweenness of all targets.

Figure 4 “Chinese medicine-active ingredient-target” network diagram. Pink: Drug; Purple: Active ingredient; Green: Target protein; RC: Rhizoma Coptidis; CM: Cinnamon; RA: Radix Astragali; PLR: Puerariae Lobatae Radix; Drug: Jiawei Jiaotai pill.

Figure 5 GO pathway bar chart. MF: Molecular function; CC: Cellular component; BP: Biological process; NADP: Nicotinamide adenine dinucleotide phosphate; MAPK: Mitogen-activated protein kinases.

Figure 6 Kyoto Encyclopedia of Genes and Genomes enrichment analysis bar chart. HIF: Hypoxia-inducible factor; IL: Interleukin; EGFR: Epidermal growth factor receptor; TNF: Tumor necrosis factor; MAPK: Mitogen-activated protein kinases.

Figure 7 Molecular docking 3D model of some key targets and active ingredients. A: Insulin-Quercetin; B: Interleukin-6-Quercetin; C: Epidermal growth factor receptor-Quercetin; D: Tumor necrosis factor-Quercetin; E: Tumor antigen p53 (TP53)-Quercetin; F: TP53-Isorhamnetin.