Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2023; 14(11): 1659-1671
Published online Nov 15, 2023. doi: 10.4239/wjd.v14.i11.1659
Molecular targets and mechanisms of Jiawei Jiaotai Pill on diabetic cardiomyopathy based on network pharmacology
Yu-Juan Wang, Yan-Li Wang, Xiao-Fan Jiang, Juan-E Li
Yu-Juan Wang, Department of Otolaryngology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaaxi Province, China
Yan-Li Wang, Department of Pediatrics, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Xiao-Fan Jiang, Juan-E Li, Department of Chinese Medicine, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaaxi Province, China
Author contributions: Wang YJ and Wang YL contributed to the literature search; Jiang XF performed the data acquisition and statistical analysis; Li JE contributed to the manuscript preparation and editing; All authors have approved the final manual.
Supported by Natural Science Basic Research Plan in the Shaanxi Province of China, No. 2021JM-549, The Plan Project of Shaanxi Provincial Administration of Traditional Chinese Medicine, No. 2021-ZZ-JC011; and The Second Youth Science and Technology Talents Project of Shaanxi Provincial Administration of Traditional Chinese Medicine, No. 2023-ZQNY-017.
Institutional review board statement: The data used in this study are all public data from public databases, and do not involve human or animals data, so there is no need for ethical review.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The data used for this study can be obtained from the corresponding authors at lizhuan-1980@126.com.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan-E Li, MD, Associate Chief Physician, Department of Chinese Medicine, Shaanxi Provincial People’s Hospital, No. 256 Youyi West Road, Beilin District, Xi’an 710068, Shaaxi Province, China. lizhuan-1980@126.com
Received: June 20, 2023
Peer-review started: June 20, 2023
First decision: July 7, 2023
Revised: July 12, 2023
Accepted: October 8, 2023
Article in press: October 8, 2023
Published online: November 15, 2023
Processing time: 146 Days and 22.7 Hours
Core Tip

Core Tip:Jiawei Jiaotai Pill is composed of Rhizoma Coptidis, Cinnamon, Radix Astragali, and Puerariae Lobatae Radix. It is mainly used to treat disharmony between the heart and kidneys, insomnia, sore mouth, and the tongue. It is often used to improve apoptosis, increase insulin secretion, and improve blood sugar tolerance. However, there are no reports on the mechanism of Jiawei Jiaotai Pills in the treatment of diabetic cardiomyopathy. We used the network pharmacology method, starting from the drug target, focused on analyzing the biological processes and conducting enrichment analysis of the important targets, and used molecular docking technology to verify the results.