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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2017; 8(4): 130-134
Published online Apr 15, 2017. doi: 10.4239/wjd.v8.i4.130
Published online Apr 15, 2017. doi: 10.4239/wjd.v8.i4.130
Syndecan-1-coating of interleukin-17-producing natural killer T cells provides a specific method for their visualization and analysis
Anil Kumar Jaiswal, Mohanraj Sadasivam, Abdel Rahim A Hamad, Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, United States
Author contributions: All authors contributed to conception and writing of this article.
Conflict-of-interest statement: Authors declare no coflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Abdel Rahim A Hamad, BVSC, PhD, Associate Professor of Pathology and Medicine, Department of Pathology, Johns Hopkins University, School of Medicine, Ross 66G, 720 Rutland Ave, Baltimore, MD 21205, United States. ahamad@jhmi.edu
Telephone: +1-410-6143021 Fax: +1-410-6143548
Received: November 13, 2016
Peer-review started: November 24, 2016
First decision: January 16, 2017
Revised: January 27, 2017
Accepted: February 18, 2017
Article in press: February 20, 2017
Published online: April 15, 2017
Processing time: 141 Days and 12.3 Hours
Peer-review started: November 24, 2016
First decision: January 16, 2017
Revised: January 27, 2017
Accepted: February 18, 2017
Article in press: February 20, 2017
Published online: April 15, 2017
Processing time: 141 Days and 12.3 Hours
Core Tip
Core tip: Discrete subsets of innate-like Natural killer T (NKT) cells differentially produce three of the most potent and polarizing cytokines, interferon-γ (NKT1), interleukin (IL)-4 (NKT2) and IL-17 (NKT17). But very little is known about how the relationship among the functional subsets of NKT cells is regulated. A major obstacle was the absence of specific single surface markers that reliably identify each subset. Here we highlight our discovery of syndecan-1 as a specific marker of NKT17 subset and its significance for understanding the role of NKT17 in glucose metabolism and autoimmunity.