Cordera R, Adami GF. From bariatric to metabolic surgery: Looking for a “disease modifier” surgery for type 2 diabetes. World J Diabetes 2016; 7(2): 27-33 [PMID: 26839653 DOI: 10.4239/wjd.v7.i2.27]
Corresponding Author of This Article
Renzo Cordera, MD, Professor of Endocrinology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy. record@unige.it
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jan 25, 2016; 7(2): 27-33 Published online Jan 25, 2016. doi: 10.4239/wjd.v7.i2.27
From bariatric to metabolic surgery: Looking for a “disease modifier” surgery for type 2 diabetes
Renzo Cordera, Gian Franco Adami
Renzo Cordera, Department of Internal Medicine, University of Genova, 16132 Genova, Italy
Gian Franco Adami, Department of Surgery, University of Genova, 16132 Genova, Italy
Author contributions: Authors equally contributed to this review article from its conception to critically analyzing literature, drafting and editing the manuscript.
Conflict-of-interest statement: Authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Renzo Cordera, MD, Professor of Endocrinology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy. record@unige.it
Telephone: +39-10-3538947
Received: July 24, 2015 Peer-review started: July 30, 2015 First decision: October 30, 2015 Revised: December 8, 2015 Accepted: December 29, 2015 Article in press: January 4, 2016 Published online: January 25, 2016 Processing time: 175 Days and 9.3 Hours
Core Tip
Core tip: In severely obese patients with type 2 diabetes mellitus (T2DM), weight loss after bariatric surgery is often accompanied by long term remission of T2DM and other obesity co-morbidities, these anti-diabetic outcomes are due both to body fat loss and to still unknown factors specifically regulated by surgery. On the other hand, the same surgical procedures in obese patients with a body mass index < 35, are associated with T2DM remission in only 50% of subjects. These findings raise the question whether bariatric surgery could be considered a metabolic one. We propose that “bariatric” surgery could be considered “metabolic” only in the case that it could demonstrate its effect on long lasting T2DM remission in morbid as well as in non-morbid obese subjects.
