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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 10, 2016; 7(15): 302-315
Published online Aug 10, 2016. doi: 10.4239/wjd.v7.i15.302
Pharmacogenetic studies update in type 2 diabetes mellitus
Shalini Singh, Kauser Usman, Monisha Banerjee
Shalini Singh, Monisha Banerjee, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, India
Kauser Usman, Department of Medicine, King George’s Medical University, Lucknow 226003, India
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Monisha Banerjee, Professor, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, University Road, Lucknow 226007, India. banerjee_monisha30@rediffmail.com
Telephone: +91-98-39500439
Received: March 29, 2016
Peer-review started: March 31, 2016
First decision: May 17, 2016
Revised: May 30, 2016
Accepted: June 27, 2016
Article in press: June 29, 2016
Published online: August 10, 2016
Processing time: 133 Days and 8.9 Hours
Core Tip

Core tip: Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder, characterized by chronic hyperglycemia. It results from an interaction of environmental as well as genetic factors. Several genes have been identified associated with disease development and therapeutic outcomes. Inter-individual variations in the human genome affect both, risk of T2DM development and personalized response to identical drug therapies. Pharmacogenetic approaches focus on single nucleotide polymorphisms and their influence on individual drug response, efficacy and toxicity. In the present study, an effort has been made to review the genetic polymorphisms in candidate genes associated with efficacy of oral antidiabetic drugs.