Gur EB, Karadeniz M, Turan GA. Fetal programming of polycystic ovary syndrome. World J Diabetes 2015; 6(7): 936-942 [PMID: 26185601 DOI: 10.4239/wjd.v6.i7.936]
Corresponding Author of This Article
Muammer Karadeniz, MD, Department of Endocrinology, Faculty of Medicine, Sifa University, Sanayi St. No. 7, Bornova 35100, Turkey. muammermd@hotmail.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Esra Bahar Gur, Guluzar Arzu Turan, Department of Obstetrics and Gynecology, Sifa University Faculty of Medicine, Izmir 35100, Turkey
Muammer Karadeniz, Department of Endocrinology, Faculty of Medicine, Sifa University, Bornova 35100, Turkey
Author contributions: Gur EB, Karadeniz M and Turan GA contributed to this paper.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Muammer Karadeniz, MD, Department of Endocrinology, Faculty of Medicine, Sifa University, Sanayi St. No. 7, Bornova 35100, Turkey. muammermd@hotmail.com
Telephone: +90-232-3434445 Fax: +90-232-3435656
Received: October 20, 2014 Peer-review started: October 21, 2014 First decision: January 20, 2015 Revised: February 23, 2015 Accepted: March 30, 2015 Article in press: April 2, 2015 Published online: July 10, 2015 Processing time: 263 Days and 14.6 Hours
Core Tip
Core tip: Polycystic ovary syndrome (PCOS) is a highly complex and heterogeneous disorder that is significantly influenced by genetic and environmental factors. There is some evidence that the development of PCOS may begin during the intrauterine period. Fetuses exposed to intrauterine nutritional restriction often have lowered insulin secretion and, as a compensatory mechanism, insulin resistance, which is known as the “thrifty” phenotype. Additionally, an impaired intrauterine nutritional environment can affect the methylation of some specific genes, which can trigger PCOS. The other hypothesis postulates that fetal exposure to excess androgen can induce changes in differentiating tissues, causing the PCOS phenotype and related disorders to develop in adult life.
