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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2015; 6(4): 654-661
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.654
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.654
Role of peroxisome proliferator-activated receptors gene polymorphisms in type 2 diabetes and metabolic syndrome
Chen Dong, Hui Zhou, Yong-Hong Zhang, Zhi-Rong Guo, Department of Epidemiology, School of Public Health, Soochow University, Suzhou 215123, Jiangsu Province, China
Hui Zhou, Lu-Gang Yu, Yi Ding, Suzhou Industrial Park Centers for Disease Control and Prevention, Suzhou 215123, Jiangsu Province, China
Chong Shen, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Author contributions: Dong C and Guo ZR proposed the manuscript concept and surveyed the literature; Zhou H, Shen C, Yu LG, Ding Y and Zhang YH generated relevant background and expanded the manuscript.
Conflict-of-interest: All of authors declared that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Rong Guo, MD, Department of Epidemiology, School of Public Health, Soochow University, 199 Ren’ai Road, Industrial Park District, Suzhou 215123, Jiangsu Province, China. guozhirong28@163.com
Telephone: +86-512-65880079 Fax: +86-512-65884830
Received: August 28, 2014
Peer-review started: August 28, 2014
First decision: December 17, 2014
Revised: December 27, 2014
Accepted: February 9, 2015
Article in press: February 11, 2015
Published online: May 15, 2015
Processing time: 260 Days and 4.4 Hours
Peer-review started: August 28, 2014
First decision: December 17, 2014
Revised: December 27, 2014
Accepted: February 9, 2015
Article in press: February 11, 2015
Published online: May 15, 2015
Processing time: 260 Days and 4.4 Hours
Core Tip
Core tip: Recently, more and more studies indicated that the gene polymorphism influence of peroxisome proliferator-activated receptors (PPARs), including PPARα, PPARβ/δ and PPARγ, acted as a pivotal role in the onset and progressing of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). We reviewed the recent advances in the relationships between PPARs polymorphisms and MetS and T2DM. Also, we discussed the effects of gene-gene interaction among PPARs genes on the MetS and T2DM herein.