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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2015; 6(3): 456-480
Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.456
Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.456
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Surapon Tangvarasittichai, Chronic Disease Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand
Author contributions: Tangvarasittichai S and his assistances performed the literatures review search and wrote the manuscript; Tangvarasittichai S designed essential ideas, drawing figures and sequencing of this review manuscript, also provided references and edited the manuscript, addressed the responses to reviewers’ concerns and contributed to the edition of the manuscript.
Conflict-of-interest: The author declares that there are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Surapon Tangvarasittichai, Associate Professor, Chronic Disease Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, 99 Moo 9 Tambon Tha Pho, Muang, Phitsanulok 65000, Thailand. surapon14t@yahoo.com
Telephone: +66-08-96388382 Fax: +66-08-55966300
Received: September 3, 2014
Peer-review started: September 4, 2014
First decision: November 14, 2014
Revised: December 25, 2014
Accepted: January 9, 2015
Article in press: January 12, 2015
Published online: April 15, 2015
Processing time: 228 Days and 16 Hours
Peer-review started: September 4, 2014
First decision: November 14, 2014
Revised: December 25, 2014
Accepted: January 9, 2015
Article in press: January 12, 2015
Published online: April 15, 2015
Processing time: 228 Days and 16 Hours
Core Tip
Core tip: Oxidative stress is underling in the development of cardiovascular disease, type 2 diabetes mellitus (T2DM) and diabetic complications. Increased oxidative stress appears to be a deleterious factor leading to insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance and ultimately leading to T2DM.