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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2015; 6(3): 432-444
Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.432
Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.432
Diabetic neuropathic pain: Physiopathology and treatment
Anne K Schreiber, Carina FM Nones, Renata C Reis, Juliana G Chichorro, Joice M Cunha, Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba 81540-970, Brazil
Author contributions: All authors contributed equally to this work.
Conflict-of-interest: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Joice M Cunha, Professor, Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Rua XV de Novembro, 1299 - Centro, Curitiba 81540-970, Brazil. joice.cunha@ufpr.br
Telephone: +55-41-33611720 Fax: +55-41-32662042
Received: August 29, 2014
Peer-review started: August 30, 2014
First decision: November 14, 2014
Revised: November 26, 2014
Accepted: February 4, 2015
Article in press: February 9, 2015
Published online: April 15, 2015
Processing time: 234 Days and 8.2 Hours
Peer-review started: August 30, 2014
First decision: November 14, 2014
Revised: November 26, 2014
Accepted: February 4, 2015
Article in press: February 9, 2015
Published online: April 15, 2015
Processing time: 234 Days and 8.2 Hours
Core Tip
Core tip: Diabetic neuropathic pain is a common complication of diabetes and the most common form of neuropathic pain. In this review, we will discuss the various factors that may contribute to the pathogenesis of diabetic neuropathic pain, including metabolic, vascular, autoimmune and oxidative stress-related mechanisms. In addition, we will review the possibilities of pain treatment, taken into consideration the first line drugs clinically used, the antidepressants and anticonvulsants, but also other options such as opioids, tapentadol and drugs for topical use, such as lidocaine and capsaicin cream.