Twito O, Frankel M, Nabriski D. Impact of glucose level on morbidity and mortality in elderly with diabetes and pre-diabetes. World J Diabetes 2015; 6(2): 345-351 [PMID: 25789117 DOI: 10.4239/wjd.v6.i2.345]
Corresponding Author of This Article
Dr. Orit Twito, Endocrinology, Diabetes and Metabolism Institute, Meir Medical Center, 59 Tschernihovsky, St., Kfar Saba 44281, Israel. orit.twito@clalit.org.il
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Mar 15, 2015; 6(2): 345-351 Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.345
Impact of glucose level on morbidity and mortality in elderly with diabetes and pre-diabetes
Orit Twito, Meir Frankel, Dan Nabriski
Orit Twito, Meir Frankel, Dan Nabriski, Endocrinology, Diabetes and Metabolism Institute, Meir Medical Center, Kfar Saba 44281, Israel
Author contributions: Twito O proposed the initial idea of the paper, wrote part of the paper and read and approved the final manuscript; Frankel M wrote part of the paper, and read and approved the final manuscript; Nabriski D made critical revisions, and read and approved the final manuscript.
Conflict-of-interest: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Orit Twito, Endocrinology, Diabetes and Metabolism Institute, Meir Medical Center, 59 Tschernihovsky, St., Kfar Saba 44281, Israel. orit.twito@clalit.org.il
Telephone: +972-9-7472788 Fax: +972-9-7471644
Received: August 28, 2014 Peer-review started: August 28, 2014 First decision: September 19, 2014 Revised: October 30, 2014 Accepted: December 29, 2014 Article in press: December 31, 2014 Published online: March 15, 2015 Processing time: 203 Days and 4.4 Hours
Core Tip
Core tip: The prevalence of diabetes mellitus (DM) and pre-diabetes in old age is very high. However, clinical guidelines do not provide complete information to the clinician managing patients with these conditions. Pre-diabetes status in the elderly increases the risk for DM, but probably does not increase the risk of cardiovascular morbidity and mortality. The role of therapeutic interventions in elderly patients with pre-diabetes is not yet proven. New-onset DM in older age is associated with better glycemic control and better prognosis compared to long standing DM in this population. Nevertheless, higher glucose levels in elderly with new-onset DM are associated with increased all-cause mortality. The benefits of tight glycemic control in elderly with long standing DM are doubtful and may cause more harm than good. To conclude, more research in this field is needed. Currently, the clinical approach for DM and pre-diabetes in the elderly should be tailored to meet individual needs.
