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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 25, 2015; 6(18): 1345-1354
Published online Dec 25, 2015. doi: 10.4239/wjd.v6.i18.1345
Published online Dec 25, 2015. doi: 10.4239/wjd.v6.i18.1345
Osteocalcin as a hormone regulating glucose metabolism
Ippei Kanazawa, Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693-8501, Japan
Author contributions: Kanazawa I wrote the paper.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ippei Kanazawa, MD, PhD, Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan. ippei.k@med.shimane-u.ac.jp
Telephone: +81-853-202183 Fax: +81-853-238650
Received: August 21, 2015
Peer-review started: August 24, 2015
First decision: October 13, 2015
Revised: October 23, 2015
Accepted: December 1, 2015
Article in press: December 2, 2015
Published online: December 25, 2015
Peer-review started: August 24, 2015
First decision: October 13, 2015
Revised: October 23, 2015
Accepted: December 1, 2015
Article in press: December 2, 2015
Published online: December 25, 2015
Core Tip
Core tip: Osteocalcin, especially undercarboxylated form of osteocalcin, has an endocrine function to regulate glucose metabolism. Osteocalcin directly stimulates insulin secretion in pancreas and indirectly via increasing glucagon-like peptide-1 secretion in small intestine as well as adiponectin secretion in adipose tissue, and enhances insulin sensitivity in muscle. Therefore, osteocalcin may be an important factor linking between bone and glucose homeostasis.