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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 25, 2015; 6(12): 1223-1242
Published online Sep 25, 2015. doi: 10.4239/wjd.v6.i12.1223
Published online Sep 25, 2015. doi: 10.4239/wjd.v6.i12.1223
Molecular and biochemical trajectories from diabetes to Alzheimer’s disease: A critical appraisal
Rajat Sandhir, Smriti Gupta, Department of Biochemistry, Panjab University, Chandigarh 160014, India
Author contributions: Sandhir R and Gupta S contributed to this paper.
Conflict-of-interest statement: Authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Rajat Sandhir, Professor, Department of Biochemistry, Panjab University, Sector 14, Chandigarh 160014, India. sandhir@pu.ac.in
Telephone: +91-172-2534131-38
Received: May 6, 2015
Peer-review started: May 8, 2015
First decision: July 10, 2015
Revised: August 26, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: September 25, 2015
Processing time: 160 Days and 1 Hours
Peer-review started: May 8, 2015
First decision: July 10, 2015
Revised: August 26, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: September 25, 2015
Processing time: 160 Days and 1 Hours
Core Tip
Core tip: This review provides a synopsis in which a metabolic disturbance becomes indispensible for life and emerges as a molecular signal defect leading to a syndrome with multiple complications. Insulin is a spotlight player which draws a trajectory from diabetes to Alzheimer’s disease with multiple divergence and convergence. We have discussed their interplay to speculate their shared molecular footprints. These biochemical and molecular commonalities provide a clue to the investigators to look inside a therapy with a common experimental and clinical platform and also provide an insight for new interventions as future perspective to find a potential stone to kill two birds together.