Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Insulin sensitivity and complications in type 1 diabetes: New insights
Petter Bjornstad, Janet K Snell-Bergeon, Kristen J Nadeau, David M Maahs, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States
Petter Bjornstad, Janet K Snell-Bergeon, Kristen J Nadeau, David M Maahs, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO 80045, United States
Petter Bjornstad, Janet K Snell-Bergeon, Kristen J Nadeau, David M Maahs, Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO 80045, United States
Author contributions: Bjornstad P researched, wrote, contributed to discussion, and reviewed/edited the manuscript; Snell-Bergeon JK and Nadeau KJ researched, contributed to discussion, and reviewed/edited the manuscript; Maahs DM researched, contributed to discussion, and reviewed/edited the manuscript.
Conflict-of-interest: Drs. Bjornstad, Snell-Bergeon, Nadeau and Maahs have no conflict of interests to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Petter Bjornstad, MD, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, 13123 East 16th Avenue, Aurora, CO 80045, United States. petter.bjornstad@childrenscolorado.org
Telephone: +1-720-7771234 Fax: +1-720-7777301
Received: September 23, 2014
Peer-review started: September 23, 2014
First decision: November 13, 2014
Revised: November 27, 2014
Accepted: December 3, 2014
Article in press: December 10, 2014
Published online: February 15, 2015
Processing time: 161 Days and 20 Hours
Peer-review started: September 23, 2014
First decision: November 13, 2014
Revised: November 27, 2014
Accepted: December 3, 2014
Article in press: December 10, 2014
Published online: February 15, 2015
Processing time: 161 Days and 20 Hours
Core Tip
Core tip: Adolescents and adults with type 1 diabetes have reduced insulin sensitivity compared to their non-diabetic counterparts. Reduced insulin sensitivity is implicated in the development and progression of micro and macrovascular complications in type 1 diabetes. Clinical trials are underway investigating insulin sensitivity as a therapeutic target to prevent vascular complications in type 1 diabetes. Methods are needed to identify which patients with type 1 diabetes would benefit from treatment of insulin resistance and translation of this to clinical practice.