Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2015; 6(1): 125-135
Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.125
Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function
Yoshinori Marunaka
Yoshinori Marunaka, Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Yoshinori Marunaka, Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Yoshinori Marunaka, Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
Author contributions: Marunaka Y solely contributed to this manuscript.
Supported by Grants-in-Aid from Japan Society of the Promotion of Science, No. 25670111; by Adaptable and Seamless Technology Transfer Program through Target-Driven RD Japan Science and Technology Agency (JST), No. 2012-2013; by KIT-KPUM-KPU-KPhU Collaborative Research Program, No. 2013-2014; and by Salt Science Foundation (1235) and Cell Research Conference.
Conflict-of-interest: There is no disclosure on financial interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yoshinori Marunaka, MD, PhD, Professor and Chairman, Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan. marunaka@koto.kpu-m.ac.jp
Telephone: +81-75-2515310 Fax: +81-75-2510295
Received: August 27, 2014
Peer-review started: August 28, 2014
First decision: November 3, 2014
Revised: November 12, 2014
Accepted: November 27, 2014
Article in press: December 1, 2014
Published online: February 15, 2015
Processing time: 157 Days and 1.5 Hours
Core Tip

Core tip: This review article provides new findings on changes of body (interstitial) fluid pH in type 2 diabetes mellitus, the role of body (interstitial) fluid pH in occurrence of insulin resistance, and future possibility of treatment for type 2 diabetes mellitus from a viewpoint of improvement of body (interstitial) fluid pH.