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World J Diabetes. Aug 15, 2014; 5(4): 431-443
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.431
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.431
Inflammation in diabetic kidney disease
Patricia M García-García, María A Getino-Melián, Virginia Domínguez-Pimentel, Juan F Navarro-Gonzalez, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Juan F Navarro-González, Spanish National Coordinator of GEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética) (RedInRen 12/0021/0019, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad), 38010 Santa Cruz de Tenerife, Spain
Author contributions: García-García PM, Getino-Melián MA and Domínguez-Pimentel V reviewed the literature and wrote the first draft of the manuscript; Navarro-González JF conceived the original idea, reviewed the first draft and revised versions, and finalized the manuscript; all authors approved the final version of the manuscript to be published.
Supported by Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III-Fondo de Investigación Sanitaria), No. PI07/0870 and No. PI10/576; Ministerio de Sanidad y Política Social (Dirección General de Terapias Avanzadas y Trasplante), No. TRA-182; Sociedad Española de Nefrología y ACINEF; Research activity by Navarro-González JF is supported by Programa de Intensificación de la Actividad Investigadora, ISCIII/Canarias
Correspondence to: Juan F Navarro-González, MD, PhD, FASN, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010 Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
Telephone: +34-92-2602061 Fax: +34-92-2602349
Received: October 4, 2013
Revised: February 24, 2014
Accepted: June 10, 2014
Published online: August 15, 2014
Processing time: 308 Days and 1 Hours
Revised: February 24, 2014
Accepted: June 10, 2014
Published online: August 15, 2014
Processing time: 308 Days and 1 Hours
Core Tip
Core tip: Diabetic kidney disease is the main cause of renal insufficiency. This complication results from interactions of genetic and environmental factors that trigger a complex network of pathophysiological events. Inflammation has emerged as a key pathophysiology mechanism with important implications from a therapeutic perspective.