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World J Diabetes. Dec 15, 2013; 4(6): 319-323
Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.319
Enzymatic vitrectomy for diabetic retinopathy and diabetic macular edema
Manuel Diaz-Llopis, Patricia Udaondo, Jose Maria Millán, J Fernando Arevalo
Manuel Diaz-Llopis, Patricia Udaondo, Department of Ophthalmology, University and Polytechnic Hospital La Fe of Valencia, 46009 Valencia, Spain
Jose Maria Millán, Department of Genetics, Hospital Universitario La Fe of Valencia, 46009 Valencia, Spain
J Fernando Arevalo, Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States
J Fernando Arevalo, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
Author contributions: All the authors contributed to this work.
Correspondence to: Manuel Diaz-Llopis, MD, Department of Ophthalmology, University and Polytechnic Hospital La Fe of Valencia, Avenida Campanar 21, 46009 Valencia, Spain. manuel.diaz@uv.es
Telephone: +34-666-530085 Fax: +34-963-606848
Received: December 27, 2012
Revised: September 7, 2013
Accepted: September 14, 2013
Published online: December 15, 2013
Processing time: 102 Days and 1.1 Hours
Core Tip

Core tip: Diabetes mellitus might be considered as a pandemic disease with its incidence and prevalence increasing exponentially, even becoming epidemic. The aim of the present review was to analyze the clinical efficacy of the intravitreal injection of autologous plasmin enzyme in the treatment of diabetic retinopathy and diabetic macular edema and to determine the role of enzymatic vitrectomy as a therapeutic approach in such cases.