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World J Diabetes. Oct 15, 2013; 4(5): 219-225
Published online Oct 15, 2013. doi: 10.4239/wjd.v4.i5.219
Published online Oct 15, 2013. doi: 10.4239/wjd.v4.i5.219
High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?
Altan Onat, Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, 34335 Etiler, Istanbul, Turkey
Mesut Aydın, Department of Cardiology, Dicle University Medical Faculty, Diyarbakir 21280, Turkey
Günay Can, Department of Public Health, Cerrahpaşa Medical Faculty, Istanbul University, 34099, Istanbul, Turkey
Bayram Köroğlu, Servet Altay, Department of Cardiology, Siyami Ersek Center for Cardiovascular Surgery, 34668, Istanbul, Turkey
Ahmet Karagöz, Section of Cardiology, Giresun Eğitim Hospital, 28000 Giresun, Turkey
Author contributions: Onat A designed the study and wrote the manuscript; Aydın M, Karagöz A, Altay S and Köroğlu B collected data, revised critically for intellectual content and approved the final version; Can G provided data analyses and approved the final version.
Supported by The Turkish Society of Cardiology
Correspondence to: Altan Onat, Professor, Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Nisbetiye cad. 59/24, 34335 Etiler, Istanbul, Turkey. alt_onat@yahoo.com.tr
Telephone: +90-212-3516217 Fax: +90-212-2211754
Received: May 30, 2013
Revised: August 16, 2013
Accepted: August 28, 2013
Published online: October 15, 2013
Processing time: 138 Days and 15.3 Hours
Revised: August 16, 2013
Accepted: August 28, 2013
Published online: October 15, 2013
Processing time: 138 Days and 15.3 Hours
Core Tip
Core tip: The issue of whether serum adiponectin protects against cardiometabolic risk in people prone to metabolic syndrome was studied in 1224 Turkish adults at a mean of 3.8 years’ follow-up. High adiponectin levels were surprisingly positively associated independently with serum creatinine in women and further failed to protect against the development of hypertension in both sexes. In multivariable adjusted Cox proportional hazards regression analyses, protection against type-2 diabetes was apparent, but women were not protected against incident coronary heart disease by high serum adiponectin. Involvement of circulating adiponectin in autoimmune complex with loss of mainly antioxidative properties may be underlying.