Microglial metabolic reprogramming: Aucubin inhibits aldose reductase to reverse diabetic neuropathic pain

doi:10.4239/wjd.v16.i8.110285

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 8

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (255)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

HTML

237

Sum=242

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=6

Aug 15, 2025 (publication date) through Aug 17, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Diabetes. Aug 15, 2025; 16(8): 110285
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.110285

Microglial metabolic reprogramming: Aucubin inhibits aldose reductase to reverse diabetic neuropathic pain

Bin Li

Bin Li, Institution of Compared Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, China

Bin Li, Center for Integrative Physiology and Molecular Medicine, University of Saarland, Homburg 66424, Saarland, Germany

Author contributions: Li B contributed to the manuscript writing, reviewing, and editing, participated in the formal analysis, conceptualization, project administration.

Supported by the Top-level Talents Support Program of Yangzhou University; “Lv Yang Jin Feng” Outstanding Doctor of Yangzhou, No. YZLYJFJH2023YXBS169; and Natural Science Foundation of Jiangsu Province, No. BK20240907.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Bin Li, PhD, Full Professor, Institution of Compared Medicine, Yangzhou University, No. 88 South Daxue Road, Yangzhou 225009, Jiangsu Province, China. 008480@yzu.edu.cn

Received: June 4, 2025
Revised: June 15, 2025
Accepted: July 14, 2025
Published online: August 15, 2025
Processing time: 72 Days and 7.1 Hours

Core Tip

Core Tip: Zheng et al have uncovered a new anti-neuropathic function of the plant glycoside aucubin-inhibiting aldose reductase and thus preventing hyperglycaemia-driven microglial aerobic glycolysis and inflammation associated with diabetic neuropathy. This study highlights a novel metabolism-immunity axis of diabetic neuropathic pain and offers an innovative therapeutic strategy.