Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2025; 16(8): 108839
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.108839
Triglyceride glucose-body mass index is associated with cardiovascular outcomes and overall mortality in type-2 diabetes mellitus patients
Mao-Jun Liu, Sun-Min Xiang, Xin-Qun Hu
Mao-Jun Liu, Xin-Qun Hu, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Sun-Min Xiang, Department of Hospital Infection Control, Xingsha District of Hunan Provincial People's Hospital (Changsha County People's Hospital), Changsha 410100, Hunan Province, China
Co-first authors: Mao-Jun Liu and Sun-Min Xiang.
Author contributions: Liu MJ and Xiang SM contribute equally to this study as co-first authors; the study was designed by Hu XQ and Liu MJ; the manuscript was prepared by Hu XQ, Liu MJ and Xiang SM; the draft was revised by Hu XQ, Liu MJ and Xiang SM; all authors read and approved the final manuscript.
Institutional review board statement: The study was exempt from ethical review and approval, as no additional institutional review board approval was necessary for the secondary analysis.
Informed consent statement: The data for our study are derived from the Action to Control Cardiovascular Risk in Diabetes (ACCORD). All participants completed informed consent forms before participating in the study.
Conflict-of-interest statement: The authors declare that they have no competing interests.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The original data are available from the NHLBI BioLINCC. Some or all of the data sets generated and/or analyzed in the current study are not publicly available, but may be obtained from the corresponding author upon reasonable request at huxinqun@csu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Qun Hu, MD, Chief Pharmacist, Professor, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410011, Hunan Province, China. huxinqun@csu.edu.cn
Received: April 24, 2025
Revised: May 31, 2025
Accepted: July 4, 2025
Published online: August 15, 2025
Processing time: 112 Days and 15.2 Hours
Core Tip

Core Tip: This study uncovers a novel association between triglyceride-glucose index (TyG)-body mass index (BMI) and both cardiovascular outcomes and overall mortality in patients with type 2 diabetes mellitus (T2DM), based on the high-risk Action to Control Cardiovascular Risk in Diabetes cohort. It also marks the first identification of TyG-BMI as a robust predictor of future congestive heart failure, providing fresh perspectives on the risk stratification for complex T2DM patients.