Gut dysbiosis, low-grade inflammation, and renal impairment severity in elderly diabetic nephropathy

doi:10.4239/wjd.v16.i8.108245

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Aug 15, 2025; 16(8): 108245
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.108245

Gut dysbiosis, low-grade inflammation, and renal impairment severity in elderly diabetic nephropathy

Yan-Ping Shi, Zhang-Lei Pan, Jing Zhang, Ling-Yu Xue, Ming-Qiang Li

Yan-Ping Shi, Zhang-Lei Pan, Jing Zhang, Ling-Yu Xue, Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China

Ming-Qiang Li, Department of Urology, Tai’an Central Hospital Affiliated to Qingdao University, Tai’an 271000, Shandong Province, China

Author contributions: Shi YP designed the experiment; Shi YP, Pan ZL, Zhang J, Xue LY, and Li MQ drafted the work and wrote the article; Pan ZL and Zhang J collected the data; Shi YP, Xue LY, and Li MQ analyzed and interpreted the data; and all authors thoroughly reviewed and endorsed the final manuscript.

Institutional review board statement: This study was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Shandong First Medical University, Shandong Province, approval No. 2024-019.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ming-Qiang Li, Department of Urology, Tai’an Central Hospital Affiliated to Qingdao University, No. 29 Longtan Road, Tai’an 271000, Shandong Province, China. limingqiang3131@126.com

Received: April 18, 2025
Revised: June 4, 2025
Accepted: July 14, 2025
Published online: August 15, 2025
Processing time: 117 Days and 17.7 Hours

Core Tip

Core Tip: At present, there are many studies on the relationship between intestinal microbiota and inflammation level and the development of diabetes, but the relationship between intestinal microbiota and the development of diabetic nephropathy (DN) is still unclear. This study investigated elderly patients with DN and revealed that they have dysbiosis of the gut microbiota and inflammatory response, which worsen with disease progression. We expect that these results will provide reference for the prevention and treatment of secondary DN in diabetic patients.