Randomized Controlled Trial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2025; 16(8): 108166
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.108166
Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers
Yue-Qiao Gao, Ying-Hui Gao, Jun-Hui Xing
Yue-Qiao Gao, Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Ying-Hui Gao, Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Jun-Hui Xing, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Author contributions: Gao YQ conceptualization, methodology, resources, supervision, funding acquisition, and writing review & editing; Gao YH validation, Formal analysis, writing original draft; Gao YH validation, investigation, writing review & editing. All authors have read and approved the final manuscript.
Supported by Natural Science Foundation of Henan Province, No. 202300410396; and the Young Talents Promotion Project of Henan Province, No. 2021HYTP043.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki. This study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University (2025-KY-0093-002).
Clinical trial registration statement: It was not registered at the public clinical trial registration platforms.
Informed consent statement: Written informed consent was obtained from all the participants.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The dataset generated and analysed during the current study is available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Hui Xing, MD, PhD, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Eastern Road, Zhengzhou 450000, Henan Province, China. xjunhui404@163.com
Received: April 7, 2025
Revised: May 20, 2025
Accepted: July 2, 2025
Published online: August 15, 2025
Processing time: 129 Days and 20.8 Hours
Core Tip

Core Tip: Diabetic foot ulcers (DFUs) are a highly prevalent and serious complication of diabetes, characterized by slow wound healing and an increased risk of infection. These infections severely impact patient health, often requiring extensive medical intervention and increasing the risk of amputation. Vitamin D plays a critical role in immune regulation and wound healing. This study found that vitamin D supplementation effectively reduced infection rates, enhanced wound healing, and strengthened immune responses in DFU cases. These findings suggest that vitamin D is a beneficial and safe adjunct to standard DFU care, potentially mitigating infection-related complications and improving clinical outcomes.