Hyperglycemia-induced overexpression of CREB3 L3 promotes the epithelial-to-mesenchymal transition in bladder urothelial cells in diabetes mellitus
Qing-Guo Wu, Department of Urology, Guigang City People Hospital, Guigang 530079, Guangxi Zhuang Autonomous Region, China
Ming-Jin Zhang, Yi-Bi Lan, Chun-Lei Ma, Wei-Jin Fu, Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530022, Guangxi Zhuang Autonomous Region, China
Co-first authors: Qing-Guo Wu and Ming-Jin Zhang.
Author contributions: Lan YB and Ma CL performed conceptualization, methodology, data curation, visualization, investigation, and writing of the original draft; Zhang MJ and Fu WJ were responsible for the project administration; Wu QG and Fu WJ were responsible for supervision, funding acquisition, resources, and review and editing of the manuscript. Wu QG and Zhang MJ contributed equally to this work.
Supported by Guangxi Natural Science Foundation, No. 2024GXNSFAA010031.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University (2023-E046-01).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Care and Use Committee of the First Affiliated Hospital of Guangxi Medical University (2023-S753-01).
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Wei-Jin Fu, Chief Physician, Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qinxiu District, Nanning 530022, Guangxi Zhuang Autonomous Region, China.
fwjgxmu1978@163.com
Received: April 7, 2025
Revised: May 8, 2025
Accepted: July 2, 2025
Published online: August 15, 2025
Processing time: 131 Days and 20.1 Hours
