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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2025; 16(8): 106833
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.106833
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.106833
Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1ser637
Jie Li, Ming Gao, Jia-Xin Wang, Hong-Yan Li, Pin Wang, Song-Yun Zhang, Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Jie Li, Ming Gao, Song-Yun Zhang, Hebei Key Laboratory of Rare Disease, Hebei Provincial Department of Science and Technology, Shijiazhuang 050000, Hebei Province, China
Fang Yuan, Department of Physiology, Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Ai-Jing Liu, Department of Immunology and Rheumatology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Co-first authors: Jie Li and Ming Gao.
Author contributions: Li J curated the dataset and wrote the original draft; Li J and Gao M validated the experimental results, they contributed equally to this article, they are the co-first authors of this manuscript; Gao M and Zhang SY conceived the study and designed the research framework; Gao M, Yuan F, and Zhang SY designed the protocol; Li J, Gao M, Wang JX, Wang P, Yuan F, and Liu AJ performed the experiments and collected the data; Li HY corrected the draft and designed figures and table; Yuan F supervised the research team; Zhang SY provided essential resources for this study; Zhang SY and Gao M secured research funding to support this work; and all authors agree to be accountable for all aspects of work ensuring integrity and accuracy.
Supported by the Natural Science Foundation of Hebei Province, No. H2021206187 and No. H2021206452.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Second Hospital of Hebei Medical University, approval No. 2021AE255.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analyzed during the study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Song-Yun Zhang, PhD, Department of Endocrinology, The Second Hospital of Hebei Medical University, Hepingxi Road, Shijiazhuang 050000, Hebei Province, China. zhangsongyun2014@126.com
Received: March 12, 2025
Revised: April 30, 2025
Accepted: July 7, 2025
Published online: August 15, 2025
Processing time: 156 Days and 4.3 Hours
Revised: April 30, 2025
Accepted: July 7, 2025
Published online: August 15, 2025
Processing time: 156 Days and 4.3 Hours
Core Tip
Core Tip: The expression of transient receptor potential melastatin 7 (TRPM7) was increased in diabetic cognitive dysfunction (DCD) mice and hippocampal neurons treated with high-concentration glucose. TRPM7 promoted mi