Case Control Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2025; 16(8): 105532
Published online Aug 15, 2025. doi: 10.4239/wjd.v16.i8.105532
Intraoperative blood perfusion factors in free anterolateral thigh flap repair for diabetic foot ulcers: A retrospective analysis
Hong-Liang Wu, Huan Huang, Bin-Qi Chen, Jian Xia, Li-Bing Jiang
Hong-Liang Wu, Huan Huang, Bin-Qi Chen, Jian Xia, Li-Bing Jiang, Department of Orthopaedics, The First Hospital of Nanchang, Nanchang 330008, Jiangxi Province, China
Author contributions: Jiang LB designed the experiments and conducted clinical data collection; Huang H, Chen BQ and Xia J performed postoperative follow-up and recorded the data; Wu HL and Jiang LB conducted the collation and statistical analysis, and wrote the original manuscript and revised the paper; All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Hospital of Nanchang, No. IIT2024018.
Informed consent statement: The ethics committee agrees to waive informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Bing Jiang, Department of Orthopaedics, The First Hospital of Nanchang, No. 128 Xiangshan North Road, Donghu, Nanchang 330008, Jiangxi Province, China. lijoy1126@163.com
Received: February 18, 2025
Revised: April 9, 2025
Accepted: July 4, 2025
Published online: August 15, 2025
Processing time: 176 Days and 18.6 Hours
Core Tip

Core Tip: This study investigates the key factors influencing intraoperative blood perfusion in patients with type 2 diabetes undergoing free anterolateral thigh perforator flap repair for diabetic foot ulcers. We identified that prolonged diabetes duration, elevated glycated hemoglobin, and poor nutritional status significantly impair perfusion. Conversely, higher hemoglobin, albumin, and prealbumin levels were protective. These findings underscore the importance of integrated diabetes management strategies, including metabolic control and nutritional support, to optimize surgical outcomes. Prospective studies are needed to validate these results and refine perioperative care protocols for improved patient outcomes.