Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2025; 16(6): 104177
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.104177
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.104177
Correlation between serum advanced glycation end-products and their receptor-mediated oxidative stress and perinatal outcomes in gestational diabetes mellitus
Ying Zhang, Zhi-Heng Wang, Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
Teng Li, Department of Interventional Radiology, The People’s Hospital of Weifang City, Weifang 261041, Shandong Province, China
Yun Liu, Department of Hematology, The People’s Hospital of Weifang City, Weifang 261041, Shandong Province, China
Author contributions: Zhang Y designed the research and wrote the manuscript draft; Zhang Y, Li T, Wang ZH, and Liu Y contributed to conceptualization and data analysis; Zhang Y and Liu Y conducted analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Obstetrics and Gynecology Hospital of Fudan University.
Informed consent statement: All study participants or their legal guardian provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun Liu, Department of Hematology, The People’s Hospital of Weifang City, No. 151 Guangwen Street, Kuiwen District, Weifang 261041, Shandong Province, China. yun.1100@163.com
Received: January 8, 2025
Revised: March 17, 2025
Accepted: May 7, 2025
Published online: June 15, 2025
Processing time: 156 Days and 4.2 Hours
Revised: March 17, 2025
Accepted: May 7, 2025
Published online: June 15, 2025
Processing time: 156 Days and 4.2 Hours
Core Tip
Core Tip: Advanced glycation end-products (AGEs) are a complex and highly heterogeneous group of compounds formed from amino acids and reducing sugars, primarily produced during thermal and metabolic processing of food. To date, a few studies have demonstrated the role of AGEs in gestational diabetes mellitus (GDM) pathophysiology. Therefore, in this study, we aimed to understand the association of AGEs with oxidative stress in GDM. We found that serum AGE levels were significantly correlated with patient oxidative stress status at 24-28 weeks of pregnancy and before delivery. Meanwhile, AGE level was a risk factor, and its receptor soluble receptor AGE level was a protective factor for adverse perinatal outcomes in GDM.