Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2025; 16(5): 104482
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.104482
Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children
Lan-Fang Cao, Qing-Bo Xu, Li Yang
Lan-Fang Cao, Qing-Bo Xu, Li Yang, Department of Endocrinology, Jiangxi Provincial Children’s Hospital/The Affiliated Children’s Hospital of Nanchang Medical College, Nanchang 330038, Jiangxi Province, China
Co-first authors: Lan-Fang Cao and Qing-Bo Xu.
Author contributions: Cao LF designed and conducted the research study; Xu QB contributed to data analysis and visualization; Cao LF and Xu QB contributed equally as co-first authors; Yang L supervised the project and provided conceptual guidance; and all authors contributed to writing and revising the manuscript and approved the final version submitted.
Supported by Jiangxi Provincial Health Commission Science and Technology Plan, No. SKJP220212334.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki (as revised in 2013), and approved by the Jiangxi Children’s Hospital Ethics Committee (Ethics Approval No: JXSETYY-YXKY-20240117).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data in this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Yang, Chief Physician, Professor, Department of Endocrinology, Jiangxi Provincial Children’s Hospital/The Affiliated Children’s Hospital of Nanchang Medical College, No. 1666 Diezihu Avenue, Honggutan District, Nanchang 330038, Jiangxi Province, China. yangli1@ncmc.edu.cn
Received: December 24, 2024
Revised: February 5, 2025
Accepted: February 26, 2025
Published online: May 15, 2025
Processing time: 122 Days and 16.3 Hours
Core Tip

Core Tip: This study highlights the predictive value of systemic inflammatory markers - systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio - for early kidney damage in children with newly diagnosed type 1 diabetes mellitus. SII emerged as a significant independent predictor of renal injury, with a high specificity threshold. The combination of SII with neutrophil-to-lymphocyte ratio or platelet-to-lymphocyte ratio further enhanced diagnostic accuracy. These simple, cost-effective markers provide valuable tools for early detection and intervention, paving the way for improved clinical strategies to prevent diabetic nephropathy in pediatric type 1 diabetes mellitus patients.