Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2025; 16(5): 104350
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.104350
Role of nuclear factor erythroid 2-related factor 2 in negative pressure wound therapy for diabetic foot ulcers
Hao-Jie Sun, Shan-Wen Si, Ya-Mei Ma, Xue-Kui Liu, Hou-Fa Geng, Jun Liang
Hao-Jie Sun, Xue-Kui Liu, Hou-Fa Geng, Jun Liang, Department of Endocrinology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China
Shan-Wen Si, Department of Scientific Research, Fuyang Hospital of Anhui Medical University, Fuyang 236112, Anhui Province, China
Ya-Mei Ma, Electrocardiogram Room, Fuyang Hospital of Anhui Medical University, Fuyang 236112, Anhui Province, China
Co-first authors: Hao-Jie Sun and Shan-Wen Si.
Co-corresponding authors: Hou-Fa Geng and Jun Liang.
Author contributions: Sun HJ, Geng HF, and Liang J contributed to the conception and design of the study; Si SW and Ma YM contributed to the data collection and assembly; Si SW contributed to the sample experiment; Liu XK contributed to the data analysis and interpretation; Sun HJ, Si SW, and Ma YM contributed to manuscript writing; All authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by Ethics Committee of Xuzhou Central Hospital (No. XZXY-LK-20211223-053).
Institutional animal care and use committee statement: This study does not involve animals.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The data used in the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Liang, PhD, Professor, Department of Endocrinology, Xuzhou Central Hospital, No. 199 Jiefang South Road, Xuzhou 221009, Jiangsu Province, China. mwlj521@njmu.edu.cn
Received: December 18, 2024
Revised: January 27, 2025
Accepted: March 3, 2025
Published online: May 15, 2025
Processing time: 128 Days and 16.4 Hours
Core Tip

Core Tip: This study investigated the potential of negative pressure wound therapy (NPWT) in diabetic foot ulcers (DFUs) by assessing wound healing, inflammatory markers, cytokines, growth factors, and oxidative stress. NPWT was associated with improved wound conditions and reduced inflammation, while also increasing angiogenesis markers and antioxidant defenses that may be mediated by nuclear factor erythroid 2-related factor 2 (Nrf2). The study suggests that Nrf2 could be involved in the therapeutic effects of NPWT on DFUs.