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World J Diabetes. May 15, 2025; 16(5): 101509
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.101509
Therapeutic potential of integrins in diabetic retinopathy
Li-Mei He, Sarul Borjigin, Xin-Qi Chen, Zhao-Li Yan, Ming-Jie Wang
Li-Mei He, Xin-Qi Chen, Department of Internal Medicine, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
Sarul Borjigin, Zhao-Li Yan, Ming-Jie Wang, Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
Co-corresponding authors: Zhao-Li Yan and Ming-Jie Wang.
Author contributions: He LM substantially contributed to literature search, interpretation of relevant literature, article drafting, and revision; Borjigin S and Chen XQ contributed to the interpretation of relevant literature, prepared the table and figure, and revised the paper; All authors have read and approved the final manuscript. Yan ZL and Wang MJ contributed to the conception and design of the article, supervised the entire project process, and revised the article. Yan ZL and Wang MJ contributed equally to this study as co-corresponding authors.
Supported by the Natural Science Foundation of Inner Mongolia, No. 2022MS08057; and 2022 Autonomous Region Medical and Health Science and Technology Plan Projects, No. 202202190.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Li Yan, MD, Chief Physician, Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Road, Hohhot 010000, Inner Mongolia Autonomous Region, China. aliceyzl@126.com
Received: September 18, 2024
Revised: January 17, 2025
Accepted: February 20, 2025
Published online: May 15, 2025
Processing time: 219 Days and 22.4 Hours
Core Tip

Core Tip: Diabetic retinopathy (DR) is a serious and common complication of diabetes mellitus. Prolonged high glucose levels damage microvasculature in the retina and can lead to blindness. Current treatment options are limited, warranting novel therapeutic strategies. Therapies targeting integrins have shown promise. This review outlines the current understanding of the role of integrins in DR and the findings of preclinical studies and clinical trials investigating the potential of various integrin-targeted therapies. Thus, this review paper captures the current state of the field and identifies possible avenues for further study and treatment approaches.