Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2025; 16(5): 101447
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.101447
Exercise training benefits pancreatic islet by modulating the insulin-like growth factor 1/phosphatidylinositol 3-kinase/protein kinase B pathway
Ya-Wen Wu, Chu-Yan Wu, Feng Lin, Jun-Ying Wu
Ya-Wen Wu, Jun-Ying Wu, Department of Rehabilitation Medicine, The First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Ya-Wen Wu, Feng Lin, School of Rehabilitation Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China
Chu-Yan Wu, Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Wu YW, Wu CY and Lin F designed the experiments and conducted clinical data collection, performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Wu YW, Lin F and Wu JY wrote the original manuscript and revised the paper; All authors read and approved the final manuscript.
Institutional animal care and use committee statement: The research was authorized by the Animal Ethics Committee of the First Hospital of Shanxi Medical University, confirming adherence to the required animal welfare guidelines.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Ying Wu, Chief Physician, Department of Rehabilitation Medicine, The First Hospital of Shanxi Medical University, No. 13 Jiefang South Road, Taiyuan 030001, Shanxi Province, China. wujunying777@126.com
Received: November 28, 2024
Revised: February 11, 2025
Accepted: March 25, 2025
Published online: May 15, 2025
Processing time: 147 Days and 23.6 Hours
Core Tip

Core Tip: In this study, we intended to reveal the outcomes of swimming training on pancreatic islets, blood glucose, insulin, lipids, pancreatic beta-cells, insulin-like growth factor 1 (IGF-1), and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway expression in diabetic rats. Our study elucidates how exercise training, via the modulation of the IGF-1-regulated PI3K/AKT pathway, improves islet quality and function in streptozotocin-induced diabetic rats.