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World J Diabetes. Apr 15, 2025; 16(4): 98995
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.98995
Intracellular calcium channels: Potential targets for type 2 diabetes mellitus?
Jia-Xuan Zhu, Zhao-Nan Pan, Dan Li
Jia-Xuan Zhu, Zhao-Nan Pan, Dan Li, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, Zhejiang Province, China
Author contributions: Li D designed the topic; Li D and Zhu JX conducted the data collection; Li D, Zhu JX, and Pan ZN wrote manuscript; All authors have read and approved the final manuscript.
Supported by Calygene Biotechnology Inc., No. XT[2016]008@.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan Li, PhD, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18 Chaowang Road, Hangzhou 310014, Zhejiang Province, China. lidan@zjut.edu.cn
Received: July 11, 2024
Revised: December 9, 2024
Accepted: January 23, 2025
Published online: April 15, 2025
Processing time: 231 Days and 23.7 Hours
Core Tip

Core Tip: The applicability and long-term use of drugs for type 2 diabetes mellitus (T2DM) treatment is limited due to their adverse effects. Drugs that activate AMP-activated protein kinase (AMPK) via calcium signaling exhibit fewer adverse effects such as lactic acidosis. However, the potency of these drugs is limited. Therefore, it is necessary to screen novel drugs with high efficacy but few adverse effects. The calcium channels control intracellular calcium flux, which could be potential targets for T2DM treatment via AMPK. This review summarizes 15 calcium channels, and discuss the potential of targeting these calcium channels for T2DM treatment.