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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2025; 16(4): 96176
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.96176
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.96176
Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic urinary bladder hyperactivity by reducing TRPV1 and P2X3
Guang-Yong Li, Shuai Ren, Bin-Cheng Huang, Jia-Jin Feng, Hai-Fu Tian, Mohammed Abdulkarem Al-Qaisi, Department of Urology, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China
Guang-Yong Li, Peking University First Hospital Ningxia Women's and Children's Hospital, Yinchuan 750000, Ningxia Hui Autonomous Region, China
Qiang-Qiang Wang, Qing-Jie Peng, Le-Yi Yu, Cun-Ling Ma, Shu-Zhe Fan, Xiao-Jiang Chen, Rui He, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China
Co-first authors: Guang-Yong Li and Shuai Ren.
Author contributions: Li GY and Ren S contributed equally to this work and should be considered co-first authors; Li GY was involved in acquisition of clinical data and drafting the manuscript; Yu LY, Ma CL, and Fan SZ contributed to drafting the manuscript; Tian HF, Feng JJ, Huang BC, Wang QQ, Peng QJ, and Chen XJ participated in animal experiments, data analysis, and manuscript revision; Al-Qaisi MA, Ren S, and He R revised the manuscript; All authors reviewed the manuscript before submission.
Supported by National Natural Science Foundation of China, No. 81860268 and No. 82201000; Ningxia Natural Science Foundation, No. 2021AAC02025; Ningxia Science and Technology Innovation Leading Talent Training Project; No. 2020GKLRLX06 and No. 2020GKLRLX11; Ningxia Medical University Research Project, No. XJKF240315; and Ningxia Key Research and Development Project, No. 2023BEG03021 and No. 2021BEB04034.
Institutional animal care and use committee statement: Ethical approval was obtained for the animal experiments conducted in the study (Certificate number: IACUC-NYLAC-2021-054).
Conflict-of-interest statement: No competing interests declared.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The authors consent to data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui He, PhD, Full Professor, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, No. 1160 Shengli South Street, Xingqing District, Yinchuan 750000, Ningxia Hui Autonomous Region, China. ruihe515@163.com
Received: April 28, 2024
Revised: October 1, 2024
Accepted: January 13, 2025
Published online: April 15, 2025
Processing time: 305 Days and 18.9 Hours
Revised: October 1, 2024
Accepted: January 13, 2025
Published online: April 15, 2025
Processing time: 305 Days and 18.9 Hours
Core Tip
Core Tip: Roux-en-Y gastric bypass as a metabolic surgery, effectively alleviates complications associated with diabetes. Although the mechanisms underlying diabetes-induced overactive bladder remain unclear, this study found that Roux-en-Y gastric bypass improved overactive bladder symptoms by suppressing inflammatory cytokines, reducing transient receptor potential vanilloid type 1 expression, and inhibiting ATP synthesis in bladder epithelial cells, ultimately leading to a direct inhibition of purinergic receptor P2X3 activity.