Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2025; 16(4): 104007
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.104007
Double-edged sword of L-arginine in diabetes: Exploring anti-inflammatory and antioxidant strategies
Shuai Liu, Ning Li, Jia-Jia Jin, Yong-Wei Yu
Shuai Liu, Department of Cardiology, The First People’s Hospital of Jiashan, Jiaxing 314100, Zhejiang Province, China
Ning Li, Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Jia-Jia Jin, Yong-Wei Yu, Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Co-first authors: Shuai Liu and Ning Li.
Co-corresponding authors: Jia-Jia Jin and Yong-Wei Yu.
Author contributions: Liu S and Li N contribute equally to this study as co-first authors; Yu YW and Jin JJ contribute equally to this study as co-corresponding authors; Liu S and Li N wrote the manuscript; Yu YW and Jin JJ designed the study and revised the manuscript; all listed authors consent to the submission.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Wei Yu, Assistant Professor, Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Received: December 9, 2024
Revised: January 21, 2025
Accepted: February 10, 2025
Published online: April 15, 2025
Processing time: 84 Days and 1 Hours
Core Tip

Core Tip: L-arginine (L-Arg) exhibits dose-dependent effects in diabetic cardiomyopathy, with low doses improving lipid profiles and high doses exacerbating oxidative stress and inflammation. This letter emphasizes the need for targeted interventions, such as nuclear factor erythroid 2-related factor 2 activation, nitric oxide synthase modulation, and combination therapies, to mitigate these adverse effects and enhance L-Arg’s clinical safety, offering safer therapeutic options for diabetic patients at risk of cardiovascular complications.