Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2025; 16(4): 102554
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.102554
Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
Meng Gao, Meng-Ting Dai, Guo-Hua Gong
Meng Gao, Meng-Ting Dai, Guo-Hua Gong, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
Meng Gao, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
Author contributions: Gao M and Dai MT contributed to the discussion of the literature and design of the manuscript; Gao M and Gong GH contributed to the writing and editing of the manuscript; Gong GH designed the overall concept and outline of the manuscript; All authors read and approved the final version of the manuscript to be published.
Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau, No. Y20240008; The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission, No. 2024KY138; and The Key Laboratory of School of Laboratory Medicine and Life Sciences, Wenzhou Medical University of China, No. JS2023003.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Hua Gong, PhD, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Chashan Higher Education Park, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn
Received: October 22, 2024
Revised: January 14, 2025
Accepted: February 5, 2025
Published online: April 15, 2025
Processing time: 129 Days and 23.1 Hours
Core Tip

Core Tip: In diabetes, insulin resistance and insufficient insulin release lead to a decrease in glucose uptake by muscles and fat tissues, resulting in elevated blood glucose levels, which are dangerous to human organs. The tolerance of high glucose switches the metabolism of glucose, which causes mitochondrial dysfunction. Oxidative stress induced by excess reactive oxygen species generated by dysfunctional mitochondria causes cell damage and thus stimulates proinflammatory factor production and tissue injury. Therefore, antidiabetic therapies are aimed at decreasing blood glucose and oxidative stress.