Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2025; 16(4): 101384
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.101384
Elevated waist-to-hip ratio, as an abdominal obesity index, predicts the risk of diabetic kidney injury
Di-Ni Lin, Dan Li, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Meng-Xue Zhou, Xian-En Huang, Xue-Mian Lu
Di-Ni Lin, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Meng-Xue Zhou, Xian-En Huang, Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Di-Ni Lin, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Xian-En Huang, Xue-Mian Lu, Wenzhou Key Laboratory for the Diagnosis and Prevention of Diabetic Complication, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Dan Li, Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Dian Diagnostics Group Company Limited, Hangzhou 310000, Zhejiang Province, China
Co-first authors: Di-Ni Lin and Dan Li.
Co-corresponding authors: Xian-En Huang and Xue-Mian Lu.
Author contributions: Huang XE and Lu XM were responsible for the conception, data collection; Lin DN was responsible for the data collection, manuscript comment, article writing; Li D was responsible for the background investigation, statistical analysis, methodology and manuscript preparation; Peng MM, Yang H, Lin ZZ, Ye EL, Chen WT, and Zhou MX were responsible for manuscript comment; All authors have read and approved the final manuscript.
Supported by the Science and Technology Project of Wenzhou City, No. Y20240252 and No. Y2023374.
Institutional review board statement: The study was approved by the Ethics Committee of The third Hospital of Wenzhou Medical University Institutional Review Board (Approval No. YJ2023077).
Informed consent statement: The requirement for written informed consent was waived for this study given the retrospective design of the study. All personal identifiers have been removed from the dataset, and any potentially identifiable information has been replaced with pseudonyms.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article, and data could be obtained from the corresponding authors at huangxianen@wmu.edu.cn or lu89118@medmail.com.cn upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-En Huang, Doctor, Associate Chief Physician, Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, No. 108 Wansong Road, Wenzhou 325200, Zhejiang Province, China. huangxianen@wmu.edu.cn
Received: September 13, 2024
Revised: December 14, 2024
Accepted: February 18, 2025
Published online: April 15, 2025
Processing time: 168 Days and 7.3 Hours
Core Tip

Core Tip: This study underscores the significance of waist-to-hip ratio (WHR) as an independent predictor of early renal injury in type 2 diabetes mellitus (T2DM) patients, highlighting its potential as a preventive tool for diabetic nephropathy. It reveals a strong association between elevated WHR and abnormal serum lipid levels, which are common in all stages of renal injury, suggesting a pivotal role of WHR in early detection and clinical management of T2DM-related renal complications.