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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2025; 16(4): 100113
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.100113
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.100113
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage
Mei-Jie Yuan, He-Chen Huang, Hong-Shuo Shi, Xiao-Ming Hu, Zhuo Zhao, Wei-Jing Fan, Guo-Bin Liu, Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Yu-Qi Chen, Department of Pathology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Jian Sun, Department of Medical Oncology and Cancer Institute of Integrative Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Co-corresponding authors: Jian Sun and Guo-Bin Liu.
Author contributions: Yuan MJ and Sun J conceptualized the study; Yuan MJ prepared the initial draft of the manuscript, and Fan WJ contributed to its revision; Yuan MJ, Huang HC, Shi HS, Hu XM, Zhao Z, and Chen YQ were involved in the design, execution, and analysis of the experiments; Liu GB supervised the study and secured funding; All authors reviewed and approved the final manuscript for publication.
Supported by the National Natural Science Foundation of China, No. 82274528.
Institutional review board statement: This study was approved by the Ethics committee of SHUTCM (Approval No. 2024-1443-026-01), and all participants gave their informed consent. The use of human tissue samples and data were performed in accordance with relevant guidelines and regulations.
Institutional animal care and use committee statement: All animal experiments were approved by the Animal Ethics Committee of Shanghai University of Traditional Chinese Medicine (Approval No. PZSHUTCM2303090001). All methods were performed in accordance with the relevant guidelines and regulation.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets analyzed are accessible in the gene expression omnibus database (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275847).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Bin Liu, MD, Chief Doctor, Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai 201203, China.
Received: August 7, 2024
Revised: December 17, 2024
Accepted: January 16, 2025
Published online: April 15, 2025
Processing time: 205 Days and 1.4 Hours
Revised: December 17, 2024
Accepted: January 16, 2025
Published online: April 15, 2025
Processing time: 205 Days and 1.4 Hours
Core Tip
Core Tip: The shift from the inflammatory to the proliferative stage is essential for effective treatment of diabetic foot ulcers (DFUs). Through bioinformatics analysis and experimental studies, we evaluated the role of microRNA (miR)-122-5p in DFU. MiR-122-5p was found to delay wound repair in DFU by disrupting re-epithelialization and intensifying inflammation throughout the healing process.