Retrospective Study
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World J Diabetes. Mar 15, 2025; 16(3): 94491
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.94491
Effects of glycemic indicators on early neurological outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis
Zuo-Wei Duan, Zhi-Ning Li, Yu-Jia Zhai, Teng-Fei Liu, Cui-Cui Zhang, Ting Hu, Xiu-E Wei, Liang-Qun Rong, Hai-Yan Liu
Zuo-Wei Duan, Zhi-Ning Li, Yu-Jia Zhai, Teng-Fei Liu, Cui-Cui Zhang, Xiu-E Wei, Liang-Qun Rong, Hai-Yan Liu, Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, Jiangsu Province, China
Ting Hu, Department of Neurology, Medical School of Nanjing University, Xuzhou 221006, Jiangsu Province, China
Co-corresponding authors: Zhi-Ning Li and Hai-Yan Liu.
Author contributions: Duan ZW and Li ZN conceived and designed the study; Hu T collected the data; Duan ZW, Liu TF, and Zhang CC analyzed the data, and drafted and revised the manuscript; Zhai YJ and Wei XE participated in drafting the manuscript; Rong LQ and Liu HY reviewed the manuscript and provided critical revision and final editing; All authors contributed to the article and approved the submitted version.
Supported by the Foundation of Jiangsu Provincial Commission of Health and Family Planning, No. QNRC2016353; and the Commission of Health and Family Planning Xuzhou, No. KC22206.
Institutional review board statement: The study was approved by the Ethic Committee of the Second Affiliated Hospital of Xuzhou Medical University, No. 2020122501.
Informed consent statement: All the authors listed have approved the submitted manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The data underlying this article will be shared on reasonable request to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Yan Liu, Doctor, PhD, Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, No. 32 Meijian Road, Xuzhou 221006, Jiangsu Province, China. sjnklhy0722@163.com
Received: March 27, 2024
Revised: October 1, 2024
Accepted: December 9, 2024
Published online: March 15, 2025
Processing time: 300 Days and 1.3 Hours
Core Tip

Core Tip: The benefit of intravenous thrombolysis (IVT) is due to arterial recanalization and brain tissue reperfusion, which improve neurological outcomes of patients with acute ischemic stroke (AIS) treated with IVT. There is no consensus on the influence of stress hyperglycemia (SH) on the effects of early neurological outcomes in patients with AIS treated with IVT. This study identified predictors of early neurological improvement (ENI) and early neurological deterioration (END) and demonstrated that admission hyperglycemia, fasting blood glucose, and SH ratio in patients with stroke treated with IVT are associated with END rather than ENI during the first 24 hours after admission.