Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2025; 16(2): 94976
Published online Feb 15, 2025. doi: 10.4239/wjd.v16.i2.94976
Islet β-cell function preservation by different anti-diabetic treatments in Chinese elderly patients with type 2 diabetes mellitus
Wei Ling, Yan-Chao Wang, Yi Huang, Yang-Fu Ou, Yan-Chun Jiang
Wei Ling, Department of Science Laboratory, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin 541002, Guangxi Zhuang Autonomous Region, China
Yan-Chao Wang, Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin 541100, Guangxi Zhuang Autonomous Region, China
Yi Huang, Faculty of Basic Medicine, Guilin Medical University, Guilin 541100, Guangxi Zhuang Autonomous Region, China
Yang-Fu Ou, Department of Geriatrics, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Yan-Chun Jiang, Department of Neurology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin 541002, Guangxi Zhuang Autonomous Region, China
Author contributions: Ling W design the study and draft the manuscript; Wang YC and Huang Y collect and generate the raw data; Ou YF and Jiang YC assembled and analyzed and/or interpretated the data; all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of the Nanxishan Hospital of Guangxi Zhuang Autonomous Region (Approval No. NXSYY-2024-209).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have declared that no conflict of interests exists.
Data sharing statement: The raw data are available upon reasonable request from the corresponding author at lingwei19901016@163.com.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Ling, MD, PhD, Chief Physician, Department of Science Laboratory, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, No. 46 Chongxin Road, Xiangshan District, Guilin 541002, Guangxi Zhuang Autonomous Region, China. lingwei19901016@163.com
Received: March 29, 2024
Revised: September 7, 2024
Accepted: December 3, 2024
Published online: February 15, 2025
Processing time: 276 Days and 7 Hours
Core Tip

Core Tip: In this longitudinal observational study, elderly type 2 diabetic patients receiving insulin, oral hypoglycemic drugs, or combination therapy were included to disclose their baseline and follow-up β-cell function. Results showed that islet β-cell function progressively decline regardless of any insulin supplement or oral antidiabetic treatments in Chinese elderly patients with type 2 diabetes.