Acellular fish skin grafts in diabetic foot ulcer care: Advances and clinical insights

doi:10.4239/wjd.v16.i1.100597

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Jan 15, 2025 (publication date) through Dec 2, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2025; 16(1): 100597
Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.100597

Acellular fish skin grafts in diabetic foot ulcer care: Advances and clinical insights

Yu Zhao, Quan-Quan Shen

Yu Zhao, Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China

Quan-Quan Shen, Department of Nephrology, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie 551700, Guizhou Province, China

Quan-Quan Shen, Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China

Author contributions: Zhao Y drafted the manuscript; Shen QQ designed and revised the manuscript; both authors have read and approved the final manuscript.

Supported by the Zhejiang Medical Technology Project, No. 2022RC009 and No. 2024KY645.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Quan-Quan Shen, Associate Professor, MD, Department of Nephrology, Zhejiang Provincial People’s Hospital Bijie Hospital, No. 112 Guanghui Road, Bijie 551700, Guizhou Province, China. spring198457@sina.com

Received: August 21, 2024
Revised: October 23, 2024
Accepted: November 13, 2024
Published online: January 15, 2025
Processing time: 101 Days and 13.3 Hours

Core Tip

Core Tip: This editorial explores the innovative use of acellular fish skin grafts (AFSGs) in the management of diabetic foot ulcers (DFUs). It introduces AFSGs as a bioengineered alternative that mimics the natural extracellular matrix, enhancing healing by promoting cell migration and tissue integration. The unique properties of AFSGs include reducing dressing changes, enhancing healing rates, and minimizing patient discomfort. This article calls for further randomized controlled trials to validate the effectiveness of AFSGs in diverse DFU cases and stresses the importance of a multidisciplinary approach in DFU management.