Platelet indices as predictors of poor glucoregulation in type 2 diabetes mellitus adults at Bishoftu General Hospital, Ethiopia

doi:10.4239/wjd.v15.i9.1889

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Sep 15, 2024; 15(9): 1889-1902
Published online Sep 15, 2024. doi: 10.4239/wjd.v15.i9.1889

Platelet indices as predictors of poor glucoregulation in type 2 diabetes mellitus adults at Bishoftu General Hospital, Ethiopia

Dereje Abebe Regassa, Gebeyaw Arega Berihun, Bisrat Fikadu Habtu, Woyesa Beyene Haile, Rahel Shumi Nagaash, Girum Tesfaye Kiya

Dereje Abebe Regassa, Bisrat Fikadu Habtu, Rahel Shumi Nagaash, Department of Medical Laboratory Sciences, Wolkite University, Wolkite 11330, Ethiopia

Gebeyaw Arega Berihun, Girum Tesfaye Kiya, School of Medical Laboratory Sciences, Jimma University, Jimma 47, Ethiopia

Woyesa Beyene Haile, Department of Medical Laboratory Sciences, Dire Dawa University, Dire Dawa 3000, Ethiopia

Author contributions: Regassa DA contributed to the conceptualization and design of the study; Regassa DA, Berihun GA, Habtu BF, Haile WB, Nagaash RS, and Kiya GT participated in data acquisition, analysis, and interpretation, and drafted the manuscript; All authors contributed to data analysis, drafting, and approved the final version of the manuscript for submission.

Institutional review board statement: Ethical clearance was approved by the Institutional Review Board of the Jimma University Institute of Health under Reference No. IHRPGD 84412/2022 GC. Additionally, a supplementary letter, with Reference No. BEFO/10339 dated June 13, 2022GC was obtained from the Oromia Regional Office, Department of Research Review Board. This letter was submitted to the administration office of Bishoftu General Hospital and directed to the offices of the medical laboratory head and chronic clinic head. Subsequently, it was sent to both headquarters along with a letter of support from the School of Medical Laboratory Sciences, Jimma University.

Informed consent statement: After obtaining permission from the Hospital administrator, the head of the Chronic Clinic care unit, and the head of the medical laboratory, a clear explanation of the study’s objectives, procedures, benefits, possible risks, and the participant’s right to voluntarily participate, written informed consent was obtained from each study subject. Codes were used instead of participants’ names to protect the confidentiality of the data obtained, and unauthorized access to the collected data was prohibited. For participants with abnormal platelet count indices physicians were informed to ensure appropriate treatment of these patients.

Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.

Data sharing statement: The datasets analyzed during the current study are available from the corresponding author upon reasonable request at sifaanabebe@gmail.com.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Dereje Abebe Regassa, MSc, Lecturer, Department of Medical Laboratory Sciences, Wolkite University, PO Box 07, Wolkite 11330, Ethiopia. sifaanabebe@gmail.com

Received: February 5, 2024
Revised: April 30, 2024
Accepted: August 1, 2024
Published online: September 15, 2024
Processing time: 203 Days and 15.2 Hours

Core Tip

Core Tip: The main aim of this study was to evaluate platelet indices and their ability to predict poor glucoregulation in patients with type 2 diabetes mellitus (T2DM). Platelet indices such as platelet distribution width, mean platelet volume, platelet large cell ratio, and plateletcrit showed varying levels of specificity, sensitivity, area under the curve, and cutoff value, and were identified as potential markers of poor glucoregulation in patients with type 2 diabetes. Therefore, these platelet indices could be utilized in the monitoring of patients with T2DM, especially in developing nations like Ethiopia.