Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2024; 15(8): 1811-1819
Published online Aug 15, 2024. doi: 10.4239/wjd.v15.i8.1811
Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea: Two case reports and review of literature
Ling-Hua Shen, Yan Cui, Dong-Xia Fu, Wei Yang, Sheng-Nan Wu, Hui-Zhen Wang, Hai-Hua Yang, Yong-Xing Chen, Hai-Yan Wei
Ling-Hua Shen, Yan Cui, Dong-Xia Fu, Wei Yang, Sheng-Nan Wu, Hui-Zhen Wang, Hai-Hua Yang, Yong-Xing Chen, Hai-Yan Wei, Department of Endocrinology and Metabolism, Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou 450018, Henan Province, China
Author contributions: Shen LH designed and performed the research study and wrote the manuscript; Cui Y and Fu DX designed the research and supervised the manuscript; Wang HZ and Yang HH designed the research and contributed to the analysis; Chen YX provided clinical advice; Wei HH made many suggestions for the revised manuscript; All authors have read and approved the final manuscript.
Supported by the Department of Science and Technology of Henan Province, China, No. 222102310461.
Informed consent statement: This study was approved by the Ethics Committee of the Children's Hospital Affiliated with Zhengzhou University (Approval No. 2023-K-123). Informed consent of the publication of the article or figures was obtained from the patients’ guardian.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read CARE Checklist (2016), and the manuscript was prepared and revised according to CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Yan Wei, MD, Chief Doctor, Department of Endocrinology and Metabolism, Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, No. 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou 450018, Henan Province, China. haiyanwei2009@163.com
Received: March 22, 2024
Revised: May 24, 2024
Accepted: June 18, 2024
Published online: August 15, 2024
Processing time: 125 Days and 16.8 Hours
Core Tip

Core Tip: To date there have been no reports of the c.3880C>T heterozygous variant of the ABCC8 gene in patients with diabetes mellitus. After finding that this heterozygous variant can cause transient neonatal diabetes mellitus, we determined that oral sulfonylurea a was safe and effective therapy that successfully replaced insulin in 2 patients with the c.3880C>T heterozygous variant of the ABCC8 gene. This genetic diagnosis will inform clinicians about the probable course and optimal management of diabetes in such patients.