Glymphatic function and its influencing factors in different glucose metabolism states

doi:10.4239/wjd.v15.i7.1537

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2024; 15(7): 1537-1550
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1537

Glymphatic function and its influencing factors in different glucose metabolism states

Bin Tian, Chen Zhao, Jia-Li Liang, Hui-Ting Zhang, Yi-Fan Xu, Hui-Lei Zheng, Jia Zhou, Jiang-Nian Gong, Shu-Ting Lu, Zi-San Zeng

Bin Tian, Jia-Li Liang, Yi-Fan Xu, Jiang-Nian Gong, Shu-Ting Lu, Zi-San Zeng, Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Chen Zhao, Magnetic Resonance Research Collaboration, Siemens Healthineers, Guangzhou 510620, Guangdong Province, China

Hui-Ting Zhang, Magnetic Resonance Research Collaboration, Siemens Healthineers Ltd., Wuhan 430071, Hubei Province, China

Hui-Lei Zheng, Department of Health Management, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Jia Zhou, Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Author contributions: Tian B and Zeng ZS designed and interpreted the complete data and were major contributors to writing the manuscript; Liang JL, Gong JN, Xu YF, and Lu ST helped to acquire the magnetic resonance images; Zheng HL and Zhou J helped to acquire the clinical data; Zhao C and Zhang HT assisted in processing the magnetic resonance images; Tian B was responsible for data analysis and manuscript writing; Zeng ZS was responsible for funding support and supervised the study; All authors read and approved the final manuscript.

Institutional review board statement: The participants in this study (No. 2023-K118-01) consisted of human individuals and were subjected to review and approval by the Medical Ethics Committee of The First Affiliated Hospital of Guangxi Medical University. This study has been registered in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/bin/project/edit?pid=199727) with registration number ChiCTR2300075515 (date of registration:07/09/2023).

Informed consent statement: Before their involvement, the subjects provided their informed consent by signing a consent form, expressing their agreement to participate in the study.

Conflict-of-interest statement: The authors declare that this study was conducted without any business or financial relationship that could be interpreted as a potential conflict of interest.

Data sharing statement: Subject to the Research Ethics Committee’s discretion, clinical and neuroimaging data may be shared through contact communication channels upon reasonable request from a qualified investigator.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Zi-San Zeng, MD, Chief Doctor, Professor, Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. zengzisan@aliyun.com

Received: February 26, 2024
Revised: May 13, 2024
Accepted: June 11, 2024
Published online: July 15, 2024
Processing time: 132 Days and 21.6 Hours

Core Tip

Core Tip: Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism is not well characterized. This study employed diffusion tensor imaging along the perivascular space (DTI-ALPS) index to investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states. Cerebral glymphatic system dysfunction was found to mainly occur in overt diabetes mellitus. Various clinical variables were found to affect the DTI-ALPS index in different stages of impaired glucose metabolism.